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Test Code ZNU Zinc, 24 Hour, Urine

Reporting Name

Zinc, 24 Hr, U

Useful For

Identifying the cause of abnormal serum zinc concentrations using a 24-hour urine specimen

Performing Laboratory

Mayo Clinic Laboratories in Rochester

Specimen Type

Urine


Ordering Guidance


The use of blood testing is recommended for children younger than 10 years. Order ZN_S / Zinc, Serum.



Necessary Information


24-Hour volume (in milliliters) is required.



Specimen Required


Patient Preparation: High concentrations of barium are known to interfere with this test. If barium-containing contrast media has been administered, the specimen should not be collected for at least 96 hours.

Supplies: Urine Tubes, 10 mL (T068)

Collection Container/Tube: Clean, plastic urine collection container with no metal cap or glued insert

Submission Container/Tube: Plastic urine tube or clean, plastic aliquot container with no metal cap or glued insert

Specimen Volume: 10 mL

Collection Instructions:

1. Collect urine for 24 hours.

2. Refrigerate specimen within 4 hours of completion of 24-hour collection.

3. See Metals Analysis Specimen Collection and Transport for complete instructions.

Additional Information: See Urine Preservatives-Collection and Transportation for 24-Hour Urine Specimens for multiple collections.


Specimen Minimum Volume

0.4 mL

Specimen Stability Information

Specimen Type Temperature Time Special Container
Urine Refrigerated (preferred) 28 days
  Ambient  28 days
  Frozen  28 days

Reference Values

0-17 years: Not established

≥18 years: 109-1,476 mcg/24 h

Day(s) Performed

Monday, Thursday

Test Classification

This test was developed and its performance characteristics determined by Mayo Clinic in a manner consistent with CLIA requirements. It has not been cleared or approved by the US Food and Drug Administration.

CPT Code Information

84630

LOINC Code Information

Test ID Test Order Name Order LOINC Value
ZNU Zinc, 24 Hr, U 5765-3

 

Result ID Test Result Name Result LOINC Value
8591 Zinc, 24 Hr, U 5765-3
TM8 Collection Duration 13362-9
VL5 Urine Volume 3167-4

Interpretation

Fecal excretion of zinc is the dominant route of elimination. Renal excretion is a minor, secondary elimination pathway. Normal daily excretion of zinc in the urine is in the range of 20 to 967 mcg/24 h.

 

High urine zinc associated with low serum zinc may be caused by hepatic cirrhosis, neoplastic disease, or increased catabolism.

 

High urine zinc with normal or elevated serum zinc indicates a large dietary source, usually in the form of high-dose vitamins.

 

Low urine zinc with low serum zinc may be caused by dietary deficiency or loss through exudation common in burn patients and those with gastrointestinal losses.

Clinical Reference

1. Sata F, Araki S, Murata K, Aono H. Behavior of heavy metals in human urine and blood following calcium disodium ethylenediamine tetraacetate injection: observations in heavy metal workers. J Toxicol Environ Health A. 1998;54(3):167-178

2. Afridi HI, Kazi TG, Kazi NG, et al. Evaluation of cadmium, lead, nickel and zinc status in biological samples of smokers and nonsmokers hypertensive patients. J Hum Hypertens. 2010;24(1):34-43

3. Zorbas YG, Kakuris KK, Neofitov IA, Afoninos NI. Zinc utilization in zinc-supplemented and -unsupplemented healthy subjects during and after prolonged hypokinesia. Tr Elem Electro. 2008;25(2):60-68

4. Rifai N, Horwath AR, Wittwer CT, eds. Tietz Textbook of Clinical Chemistry and Molecular Diagnostics. 6th ed. Elsevier; 2018

Report Available

2 to 5 days

Method Name

Triple-Quadrupole Inductively-Coupled Plasma Mass Spectrometry (ICP-MS/MS)