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HelpTest Code VWFMP von Willebrand Factor Multimer Analysis, Plasma
Specimen Required
Only orderable as part of a coagulation reflex. For more information see:
ALUPP / Lupus Anticoagulant Profile, Plasma
ALBLD / Bleeding Diathesis Profile, Limited, Plasma
AVWPR / von Willebrand Disease Profile, Plasma
For more information see Coagulation Guidelines for Specimen Handling and Processing.
Useful For
As a reflex component of several coagulation consultation unit codes, when indicated
When results of complementary laboratory tests are abnormally low or discordant (eg, F8A / Coagulation Factor VIII Activity Assay, Plasma; VWACT / von Willebrand Factor Activity, Plasma; and VWAG / von Willebrand Factor Antigen, Plasma)
To subtype von Willebrand disease (VWD) (primarily identify variants of type 2 VWD)
As an aid in determining appropriate treatment
Special Instructions
Method Name
Only orderable as part of a coagulation reflex. For more information see:
ALUPP / Lupus Anticoagulant Profile, Plasma
ALBLD / Bleeding Diathesis Profile, Limited, Plasma
ACBL / Bleeding Diathesis Profile, Comprehensive, Plasma
AVWPR / von Willebrand Disease Profile, Plasma
Agarose Gel Electrophoresis
Reporting Name
von Willebrand Factor Multimer, PSpecimen Type
Plasma Na CitSpecimen Stability Information
| Specimen Type | Temperature | Time | Special Container |
|---|---|---|---|
| Plasma Na Cit | Frozen | 42 days |
Reference Values
Only orderable as part of a coagulation reflex. For more information see:
ALUPP / Lupus Anticoagulant Profile, Plasma
ALBLD / Bleeding Diathesis Profile, Limited, Plasma
AVWPR / von Willebrand Disease Profile, Plasma
An interpretive report will be provided.
Interpretation
The plasma von Willebrand factor (VWF) multimer analysis is a qualitative visual assessment of the size spectrum and the banding pattern of vWF multimers.
This test is used to identify variants of type 2 von Willebrand disease (VWD) that have fewer of the largest multimers, have unusually large multimers, or have qualitatively abnormal "bands" that indicate an abnormal vWF structure.
Clinical Reference
1. Budde U, Schneppenheim R. von Willebrand Factor and von Willebrand Disease. Rev Clin Exp Hematol. 2001;5(4):335-368
2. Ruggeri ZM. Structure and function of von Willebrand Factor: Relationship to von Willebrand's disease. Mayo Clinic Proc. 1991;66(8):847-861
3. Sadler JE. A revised classification of von Willebrand Disease. Thromb Haemost. 1994;71(4):520-525
4. Laffan M, Brown SA, Collins PW, et al. The diagnosis of von Willebrand disease: a guideline from the UK Haemophilia Centre Doctors Organization. Haemophilia. 2004;10(3):199-217
5. Mannucci PM. Treatment of von Willebrand's Disease. N Engl J Med 2004;351(7):683-694
6. Pruthi RK, Daniels TM, Heit JA, et al. Plasma von Willebrand factor multimer quantitative analysis by in-gel immunostaining and infrared fluorescent imaging. Thrombo Res. 2010;126(6):543-549
7. Favaloro EJ and Lippi G. eds. Hemostasis and Thrombosis, Methods and Protocols. Humana Press 2017
Day(s) Performed
Monday, Tuesday
Report Available
7 to 14 daysPerforming Laboratory
Mayo Clinic Laboratories in Rochester
Test Classification
This test was developed and its performance characteristics determined by Mayo Clinic in a manner consistent with CLIA requirements. It has not been cleared or approved by the US Food and Drug Administration.CPT Code Information
85247
LOINC Code Information
| Test ID | Test Order Name | Order LOINC Value |
|---|---|---|
| VWFMP | von Willebrand Factor Multimer, P | 32217-2 |
| Result ID | Test Result Name | Result LOINC Value |
|---|---|---|
| 604411 | von Willebrand Factor Multimer, P | 32217-2 |
| 604412 | VWF Multimer Interpretation | 48595-3 |