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Test Code ULFAT Cryptococcus Antigen Titer, Lateral Flow Assay, Urine


Specimen Required


Only orderable as a reflex. For more information see ULFA / Cryptococcus Antigen Screen, Lateral Flow Assay, Random, Urine.


Useful For

Aiding in the diagnosis of infection with Cryptococcus neoformans or Cryptococcus gattii

 

This test should not be used as a test of cure.

Method Name

Only orderable as a reflex. For more information see ULFA / Cryptococcus Antigen Screen, Lateral Flow Assay, Random, Urine.

 

Lateral Flow Assay (LFA)

Reporting Name

Cryptococcus Ag Titer, LFA, U

Specimen Type

Urine

Specimen Minimum Volume

0.5 mL

Specimen Stability Information

Specimen Type Temperature Time Special Container
Urine Refrigerated (preferred) 14 days
  Frozen  14 days

Reference Values

Only orderable as a reflex. For more information see ULFA / Cryptococcus Antigen Screen, Lateral Flow Assay, Random, Urine.

Interpretation

The presence of cryptococcal antigen (CrAg) in any body fluid is strongly suggestive of infection with Cryptococcus neoformans or Cryptococcus gattii.

 

Declining titer results are suggestive of clinical response to therapy. However, monitoring CrAg titers should not be used as a test of cure, as low-level titers may persist for extended periods of time following appropriate therapy and disease resolution.

 

In addition to testing for CrAg, patients with presumed disease due to C neoformans or C gattii should have appropriate clinical specimens (eg, blood, bronchoalveolar lavage fluid) submitted for routine smear and fungal culture.

Clinical Reference

1. Hazen KC, Howell SA: Candida, Cryptococcus, and other yeasts of medical importance. In: Murray PR, ed. Manual of Clinical Microbiology. 9th ed. ASM Press; 2007:1762-1788

2. Bruner KT, Franco-Paredes C, Henao-Martinez A, et al: Cryptococcus gattii complex infections in HIV-infected patients, Southeastern United States. EID. 2018 Nov; 24(11):1998-2002. doi: 10.3201/eid2411.180787

Day(s) Performed

Monday through Friday

Report Available

1 to 4 days

Performing Laboratory

Mayo Clinic Laboratories in Rochester

Test Classification

This test has been modified from the manufacturer's instructions. Its performance characteristics were determined by Mayo Clinic in a manner consistent with CLIA requirements. This test has not been cleared or approved by the US Food and Drug Administration.

CPT Code Information

87899

LOINC Code Information

Test ID Test Order Name Order LOINC Value
ULFAT Cryptococcus Ag Titer, LFA, U 93766-4

 

Result ID Test Result Name Result LOINC Value
604369 Cryptococcus Ag Titer, LFA, U 93766-4