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HelpTest Code UHBAG Histoplasma and Blastomyces Antigen, Enzyme Immunoassay, Urine
Specimen Required
Supplies: Sarstedt Aliquot tube, 5 mL (T914)
Container/Tube: Plastic vial
Specimen Volume: 3 mL
Collection Instructions:
1. Collect a random urine specimen, with no preservative.
2. Do not centrifuge to remove particulates.
Useful For
Diagnosing Histoplasma capsulatum or Blastomyces dermatitidis infection without differentiation between the organisms
Monitor antigen levels following initiation of antifungal treatment
Method Name
Enzyme Immunoassay (EIA)
Reporting Name
Histoplasma/Blastomyces Ag, EIA, USpecimen Type
UrineSpecimen Minimum Volume
2.5 mL
Specimen Stability Information
| Specimen Type | Temperature | Time | Special Container |
|---|---|---|---|
| Urine | Refrigerated (preferred) | 14 days | |
| Frozen | 28 days | ||
| Ambient | 7 days |
Reference Values
Histoplasma/Blastomyces Antigen Result:
Not Detected
Histoplasma/Blastomyces Antigen Value:
Not Detected: 0.0 ng/mL
Detected: <1.3 ng/mL
Detected: 1.3-20.0 ng/mL
Detected: >20.0 ng/mL
Reference values apply to all ages.
Interpretation
Not detected:
No antigen from Histoplasma or Blastomyces detected. False-negative results may occur depending on extent of disease or site of infection. Repeat testing on a new specimen if clinically indicated.
Detected:
Antigen from Histoplasma or Blastomyces (unable to differentiate) was detected, below the limit of quantification (<1.3 ng/mL). Result should be correlated with clinical presentation, exposure history, and other diagnostic procedures, including culture, serology, histopathology, and radiographic findings to aid in the differentiation between histoplasmosis or blastomycosis.
Detected:
Antigen from Histoplasma or Blastomyces (unable to differentiate) detected. Result should be correlated with clinical presentation, exposure history, and other diagnostic procedures, including culture, serology, histopathology, and radiographic findings, to aid in the differentiation between histoplasmosis and blastomycosis.
Detected:
Antigen from Histoplasma or Blastomyces (unable to differentiate) detected, above the limit of quantification (>20.0 ng/mL). Result should be correlated with clinical presentation, exposure history, and other diagnostic procedures, including culture, serology, histopathology, and radiographic findings, to aid in the differentiation between histoplasmosis or blastomycosis.
Clinical Reference
1. McBride JA, Gauthier GM, Klein B. Clinical manifestations and treatment of blastomycosis. Clin Chest Med. 2017;38(3):435-449
2. Chapman SW, Dismukes WE, Proia LA, et al. Clinical practice guidelines for the management of blastomycosis. Clin Infect Dis. 2008;46(12):1801-1812
3. Wheat LJ, Freifeld AG, Kleiman MB, et al. Clinical practice guidelines for the management of patients with histoplasmosis: 2007 update by the Infectious Diseases Society of America. Clin Infect Dis. 2007;45(7):807-825
4. Granger D, Streck NT, Theel ES. Detection of Histoplasma capsulatum and Blastomyces dermatitidis antigens in serum using a single quantitative enzyme immunoassay. J Clin Microbiol. 2024;62(1):e0121323. doi:10.1128/jcm.01213-23
Day(s) Performed
Monday through Sunday
Report Available
Same day/1 to 3 daysPerforming Laboratory
Mayo Clinic Laboratories in Rochester
Test Classification
This test was developed and its performance characteristics determined by Mayo Clinic in a manner consistent with CLIA requirements. It has not been cleared or approved by the US Food and Drug Administration.CPT Code Information
87449
LOINC Code Information
| Test ID | Test Order Name | Order LOINC Value |
|---|---|---|
| UHBAG | Histoplasma/Blastomyces Ag, EIA, U | 105123-4 |
| Result ID | Test Result Name | Result LOINC Value |
|---|---|---|
| UHBAR | Histoplasma/Blastomyces Ag Result | 104871-9 |
| DEXBH | Histoplasma/Blastomyces Ag Value | 104872-7 |