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HelpTest Code TULAB Francisella tularensis Antibody, IgM and IgG, ELISA, Serum
Additional Testing Requirements
Serologic testing should be performed alongside other diagnostic methods, including culture of appropriate specimens.
Necessary Information
Call 1-800-533-1710 to notify the laboratory of suspected cases of Francisella tularensis in order to minimize exposure risk to bench technologists.
Specimen Required
Supplies: Sarstedt Aliquot Tube, 5 mL (T914)
Collection Container/Tube:
Preferred: Serum gel
Acceptable: Red top
Submission Container/Tube: Plastic vial
Specimen Volume: 0.6 mL
Collection Instructions: Centrifuge and aliquot serum into a plastic vial.
Useful For
Aiding in the diagnosis of tularemia caused by Francisella tularensis
This test should not be used as a test of cure as it is not quantitative. Patients may remain seropositive for months to years following resolution of disease.
Profile Information
| Test ID | Reporting Name | Available Separately | Always Performed |
|---|---|---|---|
| TULM | F. tularensis Ab, IgM ELISA, S | No | Yes |
| TULG | F. tularensis Ab, IgG ELISA, S | No | Yes |
| TULI | F. tularensis Interpretation | No | Yes |
Method Name
Enzyme-Linked Immunosorbent Assay (ELISA)
Reporting Name
F. tularensis Ab, IgM/IgG ELISA, SSpecimen Type
SerumSpecimen Minimum Volume
0.5 mL
Specimen Stability Information
| Specimen Type | Temperature | Time | Special Container |
|---|---|---|---|
| Serum | Refrigerated (preferred) | 7 days | |
| Frozen | 30 days |
Reference Values
IgG: Negative
IgM: Negative
Reference values apply to all ages.
Interpretation
|
IgM result |
IgG result |
Interpretation |
|
Negative |
Negative |
No antibodies to Francisella tularensis detected. Antibody response may be negative in samples collected too soon following infection/exposure. Repeat testing on a new sample in 1 to 2 weeks if clinically indicated. |
|
Positive |
Negative |
IgM class antibodies to F tularensis detected, suggesting current or recent infection. Repeat testing in 1 to 2 weeks to detect seroconversion of IgG may be considered to confirm the diagnosis. |
|
Positive |
Borderline |
|
|
Borderline |
Negative |
Questionable presence of IgM antibodies to F tularensis. Consider repeat testing in 1 to 2 weeks. |
|
Borderline |
Positive |
IgG class antibodies to F tularensis detected suggesting recent or past infection. Clinical correlation alongside presentation, exposure history and other laboratory findings required. |
|
Borderline |
Borderline |
Questionable presence of IgM and IgG class antibodies to F tularensis. Consider repeat testing in 1 to 2 weeks. |
|
Positive |
Positive |
IgM and IgG class antibodies to F tularensis detected suggesting current, recent or past infection. Cross-reactions may occur in patients with a current or prior Brucella infection. Clinical correlation alongside presentation, exposure history and other laboratory findings required. |
|
Negative |
Positive |
IgG class antibodies to F tularensis detected suggesting recent or past infection. Clinical correlation alongside presentation, exposure history and other laboratory findings required. |
|
Negative |
Borderline |
Questionable presence of IgG antibodies to F tularensis. Consider repeat testing in 1 to 2 weeks. |
Clinical Reference
1. Petersen JM, Schriefer ME, Araj GE. Francisella and Brucella. In: Carroll KC, Pfaller MA, Landry ML, et al, eds. Manual of Clinical Microbiology. 12th ed. AMS Press; 2019
2. Nigrovic LE, Wingerter SL. Tularemia. Infect Dis Clin North Am. 2008;22(3):489-504. doi:10.1016/j.idc.2008.03.004
Day(s) Performed
Tuesday, Thursday
Report Available
Same day/1 to 7 daysPerforming Laboratory
Mayo Clinic Laboratories in Rochester
Test Classification
This test has been cleared, approved, or is exempt by the US Food and Drug Administration and is used per manufacturer's instructions. Performance characteristics were verified by Mayo Clinic in a manner consistent with CLIA requirements.CPT Code Information
86668 x 2
LOINC Code Information
| Test ID | Test Order Name | Order LOINC Value |
|---|---|---|
| TULAB | F. tularensis Ab, IgM/IgG ELISA, S | 93715-1 |
| Result ID | Test Result Name | Result LOINC Value |
|---|---|---|
| TULM | F. tularensis Ab, IgM ELISA, S | 93716-9 |
| TULG | F. tularensis Ab, IgG ELISA, S | 93717-7 |
| TULI | F. tularensis Interpretation | 93718-5 |
Forms
If not ordering electronically, complete, print, and send Infectious Disease Serology Test Request (T916) with the specimen.