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Test Code TOBRA Tobramycin, Random, Serum

Important Note

 

Test has been updated in Cerner, no more need to order as a .Mayo Miscellaneous

Useful For

Monitoring adequacy of serum concentration during tobramycin therapy

 

This unit code is used whenever a specimen is submitted or collected without collection timing information. The phlebotomist should use this unit code if she or he does not know if this is a peak or trough specimen.

Method Name

Immunoassay

Reporting Name

Tobramycin, Random, S

Specimen Type

Serum


Ordering Guidance


Serum for a peak level should be drawn 30 to 60 minutes after last dose (order TOBPA / Tobramycin, Peak, Serum).

 

Serum for a trough level should be drawn no more than 30 minutes before next scheduled dose (order TOBTA / Tobramycin, Trough, Serum).



Specimen Required


Preferred: Serum gel

Acceptable: Red top

Specimen Volume: 0.5 mL

Collection Instructions:

1. Serum gel tubes should be centrifuged within 2 hours of collection.

2. Red-top tubes should be centrifuged and aliquoted within 2 hours of collection.


Specimen Minimum Volume

0.25 mL

Specimen Stability Information

Specimen Type Temperature Time Special Container
Serum Refrigerated (preferred) 7 days
  Frozen  28 days
  Ambient  72 hours

Reference Values

TOBRAMYCIN, PEAK

Therapeutic: 3.0-12.0 mcg/mL

Toxic: >12.0 mcg/mL

 

TOBRAMYCIN, TROUGH

Therapeutic: <2.0 mcg/mL

Toxic: >2.0 mcg/mL

Interpretation

Target peak concentrations depend on the type of infection being treated. Goal trough levels should be below 2.0 mcg/mL. Concentrations refer to conventional (non-pulse) dosing. Prolonged exposure to either peak levels exceeding 12.0 mcg/mL or trough levels exceeding 2.0 mcg/mL may lead to toxicity.

Clinical Reference

1. Hammett-Stabler CA, Johns T: Laboratory Guidelines for Monitoring of Antimicrobial Drugs. Clin Chem 1998;44(5):1129-1140

2. Moyer TP: Therapeutic drug monitoring. In Tietz Textbook of Clinical Chemistry. Fourth edition. Edited by CA Burtis, ER Ashwood, Philadelphia, WB Saunders Company, 2006

3. Wilson JW, Estes LL: Mayo Clinic Antimicrobial Therapy Quick Guide. Mayo Clinic Scientific Press and Informa Healthcare USA, 2008

Day(s) Performed

Monday through Sunday

Report Available

Same day/1 to 2 days

Performing Laboratory

Mayo Clinic Laboratories in Rochester

Test Classification

This test has been cleared, approved, or is exempt by the US Food and Drug Administration and is used per manufacturer's instructions. Performance characteristics were verified by Mayo Clinic in a manner consistent with CLIA requirements.

LOINC Code Information

Test ID Test Order Name Order LOINC Value
TOBRA Tobramycin, Random, S 35670-9

 

Result ID Test Result Name Result LOINC Value
TOBRA Tobramycin, Random, S 35670-9

CPT Code Information

80200 

Forms

If not ordering electronically, complete, print, and send a Therapeutics Test Request (T831) with the specimen.