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Test Code TAPNS Tapentadol and Metabolite, Serum


Specimen Required


Supplies: Sarstedt Aliquot Tube, 5 mL (T914)

Collection Container/Tube: Red top (Serum gel/SST are not acceptable)

Submission Container/Tube: Plastic vial

Specimen Volume: 1.0 mL Serum

Collection Instructions: Within 2 hours of collection, centrifuge and aliquot serum into a plastic vial.


Useful For

Monitoring medication compliance in patients who are prescribed tapentadol

Method Name

Liquid Chromatography Tandem Mass Spectrometry (LC-MS/MS)

Reporting Name

Tapentadol and Metabolite, S

Specimen Type

Serum Red

Specimen Minimum Volume

Serum: 0.5 mL

Specimen Stability Information

Specimen Type Temperature Time
Serum Red Refrigerated (preferred) 14 days
  Frozen  28 days
  Ambient  14 days

Reference Values

Tapentadol:

Therapeutic: 5-300 ng/mL

 

N-desmethyltapentadol:

No therapeutic range established

 

Cutoff concentrations by liquid chromatography tandem mass spectrometry:

Tapentadol: 0.5 ng/mL

N-desmethyltapentadol: 0.5 ng/mL

Interpretation

Serum concentrations for pain relief typically fall in the range of 5-300 ng/mL, but depend heavily on dose, frequency, and individual patient factors.

Clinical Reference

1. Langman LJ, Bechtel LK, Holstege CP. Clinical toxicology. In: Rifai N, Chiu RWK, Young I, Burnham CAD, Wittwer CT, eds. Tietz Textbook of Laboratory Medicine. 7th ed. Elsevier; 2023:Chapter 43

2. Baselt RC. Disposition of Toxic Drugs and Chemical in Man. 12th ed. Biomedical Publications; 2020

3. Jannetto PJ, Bratanow NC, Clark WA, et al. Executive Summary: American Association of Clinical Chemistry Laboratory Medicine Practice Guideline-Using Clinical Laboratory Tests to Monitor Drug Therapy in Pain Management Patients. J Appl Lab Med. 2018;2(4):489-526

Day(s) Performed

Tuesday

Report Available

3 to 7 days

Performing Laboratory

Mayo Clinic Laboratories in Rochester

Test Classification

This test was developed and its performance characteristics determined by Mayo Clinic in a manner consistent with CLIA requirements. It has not been cleared or approved by the US Food and Drug Administration.

CPT Code Information

G0480

80372 (if appropriate for select payers)

Clinical Toxicology CPT Code Client Guidance

LOINC Code Information

Test ID Test Order Name Order LOINC Value
TAPNS Tapentadol and Metabolite, S In Process

 

Result ID Test Result Name Result LOINC Value
624021 Tapentadol 59354-1
624022 N-desmethyltapentadol In Process