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Test Code SMAS Smooth Muscle Antibody Screen, Serum

Important Note

  • Physician requisition should have a capital S and a capital M if they used the acronym SM (capital S and little m is for Smith Antibody)


Specimen Required


Supplies: Sarstedt Aliquot Tube, 5 mL (T914)

Collection Container/Tube:

Preferred: Serum gel

Acceptable: Red top

Specimen Volume: 0.8 mL

Collection Instructions: Centrifuge and aliquot serum into plastic vial


Forms

If not ordering electronically, complete, print, and send 1 of the following forms with the specimen:

-General Request (T239)

-Gastroenterology and Hepatology Test Request (T728)

Useful For

Evaluation of patients with hepatitis of unknown origin associated with hypergammaglobulinemia and/or abnormal liver enzymes

Reflex Tests

Test ID Reporting Name Available Separately Always Performed
SMAT Smooth Muscle Ab Titer, S No No

Testing Algorithm

If smooth muscle antibody (SMA) screen is positive, then the SMA titer will be performed at an additional charge.

Method Name

Indirect Immunofluorescence

Reporting Name

Smooth Muscle Ab Screen, S

Specimen Type

Serum

Specimen Minimum Volume

0.4 mL

Specimen Stability Information

Specimen Type Temperature Time Special Container
Serum Refrigerated (preferred) 21 days
  Frozen  21 days

Reference Values

Negative

Reference values apply to all ages.

Interpretation

Positivity for smooth muscle antibodies (SMA) may help support a diagnosis of autoimmune hepatitis (AIH) following exclusion of other causes of hepatitis.

 

A negative result for SMA does not exclude a diagnosis of AIH.

Clinical Reference

1. European Association for the Study of the Liver. EASL clinical practice guidelines: autoimmune hepatitis. J Hepatol. 2015; 63(4):971-1004

2.  Mieli-Vergani G, Vergani D, Czaja AJ, et al. Autoimmune hepatitis. Nat Rev Dis Primers. 2018;4:18017. Published 2018 Apr 12. doi:10.1038/nrdp.2018.17

3. Sebode M, Weiler-Normann C, Liwinski T, Schramm C. Autoantibodies in Autoimmune Liver Disease-Clinical and Diagnostic Relevance. Front Immunol. 2018;9:609. Published 2018 Mar 27. doi:10.3389/fimmu.2018.00609

4. Terziroli Beretta-Piccoli B, Mieli-Vergani G, Vergani D. Autoimmune Hepatitis: Serum Autoantibodies in Clinical Practice. Clin Rev Allergy Immunol. 2022;63(2):124-137. doi:10.1007/s12016-021-08888-9

5. Bogdanos DP, Invernizzi P, Mackay IR, Vergani D. Autoimmune liver serology: current diagnostic and clinical challenges. World J Gastroenterol 2008;14:3374-87.

6. Muratori P, Granito A, Pappas G, et al. The serological profile of the autoimmune hepatitis/primary biliary cirrhosis overlap syndrome. Am J Gastroenterol. 2009;104(6):1420-1425. doi:10.1038/ajg.2009.126

Performing Laboratory

Mayo Clinic Laboratories in Rochester

Test Classification

This test was developed and its performance characteristics determined by Mayo Clinic in a manner consistent with CLIA requirements. It has not been cleared or approved by the US Food and Drug Administration.

CPT Code Information

86015

LOINC Code Information

Test ID Test Order Name Order LOINC Value
SMAS Smooth Muscle Ab Screen, S 26971-2

 

Result ID Test Result Name Result LOINC Value
609515 Smooth Muscle Ab Screen, S 26971-2

Day(s) Performed

Monday through Saturday

Report Available

2 to 4 days