Home
HelpTest Code SLA Soluble Liver Antigen (SLA) IgG Antibodies, Serum
Specimen Required
Supplies: Sarstedt Aliquot Tube, 5 mL (T914)
Collection Container/Tube:
Preferred: Serum gel
Acceptable: Red top
Submission Container/Tube: Plastic vial
Specimen Volume: 0.5 mL Serum
Collection Instructions: Centrifuge and aliquot serum into a plastic vial.
Forms
If not ordering electronically, complete, print, and send Gastroenterology and Hepatology Test Request (T728) with the specimen.
Useful For
Evaluation of patients at-risk for autoimmune hepatitis or liver disease of unknown etiology
Testing Algorithm
For information see First-Line Screening for Autoimmune Liver Disease Algorithm.
Special Instructions
Method Name
Enzyme-Linked Immunosorbent Assay (ELISA)
Reporting Name
Soluble Liver Antigen Ab, IgG, SSpecimen Type
SerumSpecimen Minimum Volume
Serum: 0.4 mL
Specimen Stability Information
| Specimen Type | Temperature | Time |
|---|---|---|
| Serum | Refrigerated (preferred) | 21 days |
| Frozen | 21 days |
Reference Values
Negative: <20.0 U
Equivocal: 20.0-24.9 U
Positive: ≥ 25.0 U
Interpretation
A positive anti-SLA (soluble liver antigen) antibody test is highly specific marker for autoimmune hepatitis (AIH), especially in cases where other antibodies are absent. It occurs in approximately 10% to 30% of patients with AIH.
Clinical Reference
1. European Association for the Study of the Liver. EASL Clinical Practice Guidelines: Autoimmune hepatitis. J Hepatol. 2015;63(4):971-1004
2. Mack CL, Adams D, Assis DN, et al. Diagnosis and management of autoimmune hepatitis in adults and children: 2019 Practice Guidance and Guidelines from the American Association for the Study of Liver Diseases. Hepatology. 2020;72(2):671-722
3. Terziroli Beretta-Piccoli B, Mieli-Vergani G, Vergani D. Autoimmune hepatitis: Serum autoantibodies in clinical practice. Clin Rev Allergy Immunol. 2022;63(2):124-137
4. Vitozzi S, Djilali-Saiah I, Lapierre P, Alvarez F. Anti-soluble liver antigen/liver-pancreas (SLA/LP) antibodies in pediatric patients with autoimmune hepatitis. Autoimmunity. 2002;35(8):485-492
5. Ballot E, Homberg JC, Johanet C. Antibodies to soluble liver antigen: an additional marker in type 1 auto-immune hepatitis. J Hepatol. 2000;33(2):208-215
6. Manns M, Gerken G, Kyriatsoulis A, et al. Characterisation of a new subgroup of autoimmune chronic active hepatitis by autoantibodies against a soluble liver antigen. Lancet. 1987;1:292-294. doi:10.1016/S0140-6736(87)92024-1
7. Gelpi C, Sontheimer EJ, Rodriguez-Sanchez JL. Autoantibodies against a serine tRNA-protein complex implicated in cotranslational selenocysteine insertion. Proc Natl Acad Sci U S A. 1992;89(20):9739-9743
8. Baeres M, Herkel J, Czaja AJ, et al. Establishment of standardised SLA/LP immunoassays: specificity for autoimmune hepatitis, worldwide occurrence, and clinical characteristics. Gut. 2002;51(2):259-264
9. Chen ZX, Shao JG, Shen Y, et al. Prognostic implications of antibodies to soluble liver antigen in autoimmune hepatitis: A PRISMA-compliant meta-analysis. Medicine (Baltimore). 2015;94(23):e953
10. Yuksekyayla O, Kina N, Ulaba A, et al. The frequency and clinical significance of antibodies to soluble liver antigen/liver pancreas in autoimmune hepatitis: a prospective single-center study. Eur J Gastroenterol Hepatol. 2024;36(5):652-656
11. Zachou K, Weiler-Normann C, Muratori L, Muratori P, Lohse AW, Dalekos GN. Permanent immunosuppression in SLA/LP-positive autoimmune hepatitis is required although overall response and survival are similar. Liver Int. 2020;40(2):368-376
Day(s) Performed
Monday
Report Available
2 to 8 daysPerforming Laboratory
Mayo Clinic Laboratories in Rochester
Test Classification
This test has been cleared, approved, or is exempt by the US Food and Drug Administration and is used per manufacturer's instructions. Performance characteristics were verified by Mayo Clinic in a manner consistent with CLIA requirements.CPT Code Information
83516
LOINC Code Information
| Test ID | Test Order Name | Order LOINC Value |
|---|---|---|
| SLA | Soluble Liver Antigen Ab, IgG, S | 32219-8 |
| Result ID | Test Result Name | Result LOINC Value |
|---|---|---|
| SLA | Soluble Liver Antigen Ab, IgG, S | 32219-8 |