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HelpTest Code SESPF Sesame Seed, IgE, with Reflex to Sesame Seed Component, IgE, Serum
Ordering Guidance
For a listing of allergens available for testing, see Allergens - Immunoglobulin E (IgE) Antibodies
Specimen Required
Supplies: Sarstedt Aliquot Tube, 5 mL (T914)
Collection Container/Tube:
Preferred: Serum gel
Acceptable: Red top
Submission Container/Tube: Plastic vial
Specimen Volume: 0.6 mL
Collection Instructions: Centrifuge and aliquot serum into a plastic vial.
Useful For
Evaluating patients with suspected sesame seed allergy
Reflex Tests
| Test ID | Reporting Name | Available Separately | Always Performed |
|---|---|---|---|
| SESPR | Sesame Seed Component, IgE, S | No | No |
Testing Algorithm
Testing begins with analysis of total sesame seed IgE. If the sesame seed total IgE result is negative (<0.10 kU/L), testing is complete.
If the sesame seed total IgE result is 0.10 kU/L or more, then sesame seed component (Ses i 1) testing will be performed at an additional charge.
Special Instructions
Method Name
Fluorescent Enzyme Immunoassay (FEIA)
Reporting Name
Sesame Seed Component Reflex, SSpecimen Type
SerumSpecimen Minimum Volume
0.4 mL
Specimen Stability Information
| Specimen Type | Temperature | Time | Special Container |
|---|---|---|---|
| Serum | Refrigerated (preferred) | 14 days | |
| Frozen | 90 days |
Reference Values
|
Class |
IgE kU/L |
Interpretation |
|
0 |
<0.10 |
Negative |
|
0/1 |
0.10-0.34 |
Borderline/equivocal |
|
1 |
0.35-0.69 |
Equivocal |
|
2 |
0.70-3.49 |
Positive |
|
3 |
3.50-17.4 |
Positive |
|
4 |
17.5-49.9 |
Strongly positive |
|
5 |
50.0-99.9 |
Strongly positive |
|
6 |
≥100 |
Strongly positive |
Concentrations of 0.70 kU/L or more (class 2 and above) will flag as abnormally high.
Reference values apply to all ages.
Interpretation
If the total serum IgE antibody against sesame seed is detectable (≥0.10 IgE kUa/L), it is possible the patient has been sensitized to the components of sesame seed or other potential substances with cross activity. An additional test utilizing Ses i 1, a specific allergenic sesame seed component IgE antibody, will be performed to further confirm sensitization to sesame seed.
If the total serum IgE antibody against sesame seed is negative (<0.10 IgE kUa/L), the patient lacks detectable sensitization to sesame seed components. A report will be provided without additional testing performed. An oral food challenge may be helpful in the diagnosis of sesame seed allergy.
Clinical Reference
1. Dalal I, Goldberg M, Katz Y. Sesame seed food allergy. Curr Allergy Asthma Rep. 2012;12(4):339-345
2. Warren CM, Chadha AS, Sicherer SH, et al. Prevalence and severity of sesame allergy in the United States. JAMA network open. 2019;2(8):e199144-e199144
3. Sokol K, Rasooly M, Dempsey C, et al. Prevalence and diagnosis of sesame allergy in children with IgE-mediated food allergy. Pediatr Allergy Immunol. 2020;31(2):214-218
4. Adatia A, Clarke AE, Yanishevsky Y, Ben-Shoshan M. Sesame allergy: current perspectives. J Asthma Allergy. 2017;10:141-151.
5. Cohen A, Goldberg M, Levy B, Leshno M, Katz Y. Sesame food allergy and sensitization in children: the natural history and long-term follow-up. Pediatr Allergy Immunol. 2007;18(3):217-223
6. Gupta RS, Lau CH, Sita EE, Smith B, Greenhawt M. Factors associated with reported food allergy tolerance among US children. Ann Allergy Asthma Immunol. 2013;111(3):194-198
7. Ziegler JB, Aalberse RC. Sesame: an increasingly popular word and common food allergen. J Allergy Clin Immunol: Pract. 2020;8(5):1689-1691
8. U.S. Food and Drug Administration. Allergic to Sesame? Food Labels Now Must List Sesame as an Allergen. Updated January 10, 2023. Accessed March 3, 2024.Available at //www.fda.gov/consumers/consumer-updates/allergic-sesame-food-labels-now-must-list-sesame-allergen
9. WHO/IUIS Allergen Nomenclature Sub-Committee. Sesamum indicum - All Allergen. Accessed March 3, 2024.Available at www.allergen.org/search.php?allergensource=Sesamum+indicum
10. Pastorello EA, Varin E, Farioli L, et al. The major allergen of sesame seeds (Sesamum indicum) is a 2S albumin. J Chromatogr B Biomed Sci Appl. 2001;756(1-2):85-93
11. Moreno FJ, Clemente A. 2S albumin storage proteins: what makes them food allergens?. Open Biochem J. 2008;2:16-28
12. Maruyama N, Nakagawa T, Ito K, et al. Measurement of specific IgE antibodies to Ses i 1 improves the diagnosis of sesame allergy. Clin Exp Allergy. 2016;46(1):163-171
13. Dreskin SC, Koppelman SJ, Andorf S, et al. The importance of the 2S albumins for allergenicity and cross-reactivity of peanuts, tree nuts, and sesame seeds. J Allergy Clin Immunol. 2021;147(4):1154-1163
14. Brough HA, Caubet JC, Mazon A, et al. Defining challenge-proven coexistent nut and sesame seed allergy: a prospective multicenter European study. J Allergy Clin Immunol. 2020;145(4):1231-1239
15. Tuano KTS, Dillard KH, Guffey D, Guffey D, Davis CM. Development of sesame tolerance and cosensitization of sesame allergy with peanut and tree nut allergy in children. Ann Allergy. 2016;117(6):708-710
16. Yanagida N, Ejiri Y, Takeishi D, et al. Ses i 1-specific IgE and sesame oral food challenge results. J Allergy Clin Immunol Pract. 2019;7(6):2084-2086
17. Saf S, Sifers TM, Baker MG et al. Diagnosis of Sesame Allergy: Analysis of Current Practice and Exploration of Sesame Component Ses i 1. J Allergy Clin Immunol Pract. 2020;8(5):1681-1688
18. Sato S, Yanagida N, Ebisawa M. How to diagnose food allergy. Curr Opin Allergy Clin Immunol. 2018;18(3):214-221
19. Foong RX, Dantzer JA, Wood RA, Santos AF. Improving Diagnostic Accuracy in Food Allergy. J Allergy Clin Immunol Pract. 2021;9(1):71-80
20. Patel A, Bahna SL. Hypersensitivities to sesame and other common edible seeds. Allergy. 2016;71(10):1405-1413
21. Segal L, Ben-Shoshan M, Alizadehfar R, et al. Initial and accidental reactions are managed inadequately in children with sesame allergy. J Allergy Clin Immunol Pract. 2017;5(2):482-485
Day(s) Performed
Monday through Friday
Report Available
Same day/1 to 3 daysPerforming Laboratory
Mayo Clinic Laboratories in Rochester
Test Classification
This test has been cleared, approved, or is exempt by the US Food and Drug Administration and is used per manufacturer's instructions. Performance characteristics were verified by Mayo Clinic in a manner consistent with CLIA requirements.CPT Code Information
86003
LOINC Code Information
| Test ID | Test Order Name | Order LOINC Value |
|---|---|---|
| SESPF | Sesame Seed Component Reflex, S | 6242-2 |
| Result ID | Test Result Name | Result LOINC Value |
|---|---|---|
| SESA1 | Sesame Seed, IgE, S | 6242-2 |