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Test Code SDLDL Small Dense Low Density Lipoprotein Cholesterol, Serum


Specimen Required


Patient Preparation: Fasting overnight (8-12 hours) required

Supplies: Sarstedt Aliquot Tube, 5 mL (T914)

Collection Container/Tube:

Preferred: Serum gel

Acceptable: Red top

Submission Container/Tube: Plastic vial

Specimen Volume: 1 mL

Collection Instructions:

1. Centrifuge and aliquot serum into a plastic vial.

2. Send frozen.


Useful For

Aiding in risk management of lipoprotein disorders associated with cardiovascular disease when used in conjunction with other lipid measurements and clinical evaluation

Method Name

Enzymatic Colorimetric

Reporting Name

Small Dense LDL Cholesterol, S

Specimen Type

Serum

Specimen Minimum Volume

0.5 mL

Specimen Stability Information

Specimen Type Temperature Time Special Container
Serum Frozen (preferred) 30 days
  Refrigerated  72 hours
  Ambient  8 hours

Reference Values

≥18 years: <50 mg/dL

Reference values have not been established for patients who are younger than 18 years.

Interpretation

Results of 50 mg/dL or greater indicate increased risk of incident coronary heart disease (CHD) (myocardial infarction, fatal CHD, or cardiac procedure).

Clinical Reference

1. Tsai MY, Steffen BT, Guan W, et al. New automated assay of small dense low-density lipoprotein cholesterol identifies risk of coronary heart disease: the multi-ethnic study of atherosclerosis. Arterioscler Thromb Vasc Biol. 2014;34(1):196-201. doi:10.1161/ATVBAHA.113.302401

2. Hoogeveen RC, Gaubatz JW, Sun W, et al. Small dense low-density lipoprotein-cholesterol concentrations predict risk for coronary heart disease: the atherosclerosis riskiIn ommunities (ARIC) study. Arterioscler Thromb Vasc Biol. 2014;34(5):1069-1077. doi:10.1161/ATVBAHA.114.303284

3. Hirano T, Ito Y, Yoshino G. Measurement of small dense low-density lipoprotein particles. J Atheroscler Thromb. 2005;12(2):67-72

4. Ogita K, Ai M, Tanaka A, et al. Circadian rhythm of serum concentration of small dense low-density lipoprotein cholesterol. Clin Chim Acta. 2007;376(1-2):96-100

5. Balling M, Nordestgaard BG, Langsted A, Varbo A, Kamstrup PR, Afzal S. Small dense low-density lipoprotein cholesterol predicts atherosclerotic cardiovascular disease in the Copenhagen general population study. J Am Coll Cardiol. 2020;75(22):2873-2875. doi:10.1016/j.jacc.2020.03.072

Day(s) Performed

Monday through Friday

Report Available

1 to 3 days

Performing Laboratory

Mayo Clinic Laboratories in Rochester

Test Classification

This test has been cleared, approved, or is exempt by the US Food and Drug Administration and is used per manufacturer's instructions. Performance characteristics were verified by Mayo Clinic in a manner consistent with CLIA requirements.

CPT Code Information

83722

LOINC Code Information

Test ID Test Order Name Order LOINC Value
SDLDL Small Dense LDL Cholesterol, S 90364-1

 

Result ID Test Result Name Result LOINC Value
SDLDL Small Dense LDL Cholesterol, S 90364-1

Forms

If not ordering electronically, complete, print, and send a Cardiovascular Test Request (T724) with the specimen.