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HelpTest Code ROPG Measles (Rubeola) Antibodies, IgG, Serum
Reporting Name
Measles (Rubeola) Ab, IgG, SUseful For
Determining immune status of individuals to the measles virus
Documenting previous infection with measles virus in an individual without a previous record of immunization to measles virus
Performing Laboratory
Mayo Clinic Laboratories in Rochester
Specimen Type
SerumSpecimen Required
Collection Container/Tube:
Preferred: Serum gel
Acceptable: Red top
Submission Instructions: Plastic vial
Specimen Volume: 0.5 mL
Collection Instructions: Centrifuge and aliquot serum into a plastic vial.
Specimen Minimum Volume
0.4 mL
Specimen Stability Information
| Specimen Type | Temperature | Time | Special Container |
|---|---|---|---|
| Serum | Refrigerated (preferred) | 14 days | |
| Frozen | 14 days |
Reference Values
Vaccinated: positive (≥1.1 AI)
Unvaccinated: negative (≤0.8 AI)
Reference values apply to all ages.
Day(s) Performed
Monday through Saturday
Test Classification
This test has been cleared, approved, or is exempt by the US Food and Drug Administration and is used per manufacturer's instructions. Performance characteristics were verified by Mayo Clinic in a manner consistent with CLIA requirements.CPT Code Information
86765
LOINC Code Information
| Test ID | Test Order Name | Order LOINC Value |
|---|---|---|
| ROPG | Measles (Rubeola) Ab, IgG, S | 77310-1 |
| Result ID | Test Result Name | Result LOINC Value |
|---|---|---|
| ROG | Measles (Rubeola) Ab, IgG, S | 35275-7 |
| DEXG3 | Measles IgG Antibody Index | 5244-9 |
Interpretation
The reported antibody index (AI) value is for reference only. This is a qualitative test, and the numeric value of the AI is not indicative of the amount of antibody present. AI values above the manufacturer recommended cutoff for this assay indicate that specific antibodies were detected, suggesting prior exposure or vaccination.
Positive: AI value of 1.1 or higher
The presence of detectable IgG-class antibodies indicates prior exposure to the measles virus through infection or immunization. Individuals testing positive are considered immune to measles infection.
Equivocal: AI value 0.9-1.0
Submit an additional sample for testing in 10 to 14 days to demonstrate IgG seroconversion if recently vaccinated or otherwise clinically indicated.
Negative: AI value of 0.8 or lower
The absence of detectable IgG-class antibodies suggests the lack of a specific immune response to immunization or no prior exposure to the measles virus.
Clinical Reference
1. Perry RT, Halsey NA: The clinical significance of measles-a review. J Infect Dis. 2004;189(Supp 1):S4-S16. doi: 10.1086/377712
2. Babbott FL, Gordon JE: Modern measles. Am J Med Sci. 1954;228:334-361
3. Liebert UG: Measles virus infections of the central nervous system. Intervirology. 1997;40(2-3):176-184
4. Centers for Disease Control and Prevention (CDC). Measles-United States, 1999. MMWR Morb Mortal Wkly Rep. 2000;49(25):557-560
5. Centers for Disease Control and Prevention (CDC). Increased transmission and outbreaks of measles-European Region, 2011. MMWR Morb Mortal Wkly Rep. 2011;60(47):1605-1610
6. Theel ES, Sorenson M, Rahman C, Granger D, Vaughn A, Breeher L: Performance characteristics of a multiplex flow immunoassay for detection of IgG-Class antibodies to measles, mumps, rubella, and Varicella-Zoster viruses in presumptively immune health care workers. J Clin Microbiol. 2020 Mar 25;58(4):e00136-20. Â doi: 10.1128/JCM.00136-20
Report Available
Same day/1 to 3 daysMethod Name
Multiplex Flow Immunoassay (MFI)
Forms
If not ordering electronically, complete, print, and send Infectious Disease Serology Test Request (T916) with the specimen.