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HelpTest Code ROGM Measles (Rubeola) Virus Antibody, IgM and IgG, Serum
Reporting Name
Measles (Rubeola) Ab, IgM and IgG,SUseful For
Diagnosing measles virus infection
Determination of immune status of individuals to the measles virus using IgG antibody testing
Documentation of previous infection with measles virus in an individual without a previous record of immunization to measles virus
Profile Information
| Test ID | Reporting Name | Available Separately | Always Performed |
|---|---|---|---|
| ROM | Measles (Rubeola) Ab, IgM, S | Yes | Yes |
| ROPG | Measles (Rubeola) Ab, IgG, S | Yes | Yes |
Performing Laboratory
Mayo Clinic Laboratories in Rochester
Specimen Type
SerumSpecimen Required
Collection Container/Tube:
Preferred: Serum gel
Acceptable: Red top
Submission Container/Tube: Plastic vial
Specimen Volume: 1 mL
Collection Instructions: Centrifuge and aliquot serum into a plastic vial.
Specimen Minimum Volume
0.6 mL
Specimen Stability Information
| Specimen Type | Temperature | Time | Special Container |
|---|---|---|---|
| Serum | Refrigerated (preferred) | 14 days | |
| Frozen | 14 days |
Reference Values
IMMUNOGLOBULIN M
Negative
Reference values apply to all ages.
IMMUNOGLOBULIN G
Vaccinated: positive (≥1.1 AI)
Unvaccinated: negative (≤0.8 AI)
Reference values apply to all ages.
Day(s) Performed
Monday through Saturday
CPT Code Information
86765-Rubeola IgM
86765-Rubeola IgG
LOINC Code Information
| Test ID | Test Order Name | Order LOINC Value |
|---|---|---|
| ROGM | Measles (Rubeola) Ab, IgM and IgG,S | 90253-6 |
| Result ID | Test Result Name | Result LOINC Value |
|---|---|---|
| 80979 | Measles (Rubeola) Ab, IgM, S | 35276-5 |
| ROG | Measles (Rubeola) Ab, IgG, S | 35275-7 |
| DEXG3 | Measles IgG Antibody Index | 5244-9 |
Interpretation
This assay tests for both IgM and IgG-class antibodies. The presence of IgM-class antibodies, with or without the presence of IgG-class antibodies, to measles virus may support a clinical diagnosis of recent/acute phase infection with the virus. IgM results alone should not be used to diagnose measles virus infection.
The absence of IgM-class antibodies suggests lack of an acute phase infection with measles virus. However, serology may be negative for IgM-class antibodies in early disease, and results should be interpreted in the context of clinical findings.
Testing for IgM-class antibodies to measles should be limited to patients with clinically compatible disease.
The presence of detectable IgG-class antibodies, in the absence of IgM-class antibodies, indicates prior exposure to the measles virus through infection or immunization. These individuals are considered immune to measles infection.
The absence of detectable IgG-class antibodies suggests the lack of a specific immune response to immunization or no prior exposure to the measles virus. These individuals are considered nonimmune to measles virus infection.
Clinical Reference
1. Perry RT, Halsey NA: The clinical significance of measles-a review. J Infect Dis. 2004 May 1;189 Supp 1:S4-S16. doi: 10.1086/377712
2. Babbott FL, Gordon JE: Modern measles. Am J Med Sci. 1954 Sep;228(3):334-361
3. Liebert UG: Measles virus infections of the central nervous system. Intervirology. 1997;40:176-184. doi: 10.1159/000150544
4. Centers for Disease Control and Prevention (CDC): Measles-United States, 1999. MMWR Morb Mortal Wkly Rep. 2000;49(25):557-560
5. Centers for Disease Control and Prevention (CDC): Increased transmission and outbreaks of Measles-European region. MMWR Morb Mortal Wkly Rep. 2011;60(47):1605-1610
6. Cremer NE, Devlin VL, Riggs JL, Hagens SJ: Anomalous antibody responses in viral infection: specific stimulation or polyclonal activation? J Clin Microbiol. 1984;20:468-472
7. Theel ES, Sorenson M, Rahman C, Granger D, Vaughn A, Breeher L: Performance characteristics of a multiplex flow immunoassay for detection of IgG-Class antibodies to measles, mumps, rubella, and Varicella-Zoster viruses in presumptively immune health care workers. J Clin Microbiol. 2020 Mar 25;58(4):e00136-20. doi: 10.1128
8. National Center for Immunization and Respiratory Diseases, Division of Viral Diseases; Centers for Disease Control and Prevention (CDC). Measles (Rubeola). CDC; Updated November 5, 2020. Accessed October 25, 2022. Available at www.cdc.gov/measles/hcp/index.html
Report Available
Same day/1 to 3 daysMethod Name
ROM: Immunofluorescence Assay (IFA)
ROPG: Multiplex Flow Immunoassay (MFI)
Test Classification
This test has been cleared, approved, or is exempt by the US Food and Drug Administration and is used per manufacturer's instructions. Performance characteristics were verified by Mayo Clinic in a manner consistent with CLIA requirements.Forms
If not ordering electronically, complete, print, and send Infectious Disease Serology Test Request (T916) with the specimen.