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HelpTest Code ROC Rubeola (Measles) Antibodies, IgG and IgM, Spinal Fluid
Reporting Name
Rubeola (Measles) Ab, IgG,IgM, CSFUseful For
Diagnosing central nervous system rubeola (measles) virus infection and/or subacute sclerosing panencephalitis
Performing Laboratory
Mayo Clinic Laboratories in Rochester
Specimen Type
CSFSpecimen Required
Container/Tube: Sterile vial
Specimen Volume: 0.25 mL
Specimen Minimum Volume
0.1 mL
Specimen Stability Information
| Specimen Type | Temperature | Time | Special Container |
|---|---|---|---|
| CSF | Refrigerated (preferred) | 14 days | |
| Frozen | 14 days |
Reference Values
IgG: <1:5
IgM: <1:10
Reference values apply to all ages.
Day(s) Performed
Monday through Friday
Test Classification
This test was developed and its performance characteristics determined by Mayo Clinic in a manner consistent with CLIA requirements. It has not been cleared or approved by the US Food and Drug Administration.CPT Code Information
86765 x 2
LOINC Code Information
| Test ID | Test Order Name | Order LOINC Value |
|---|---|---|
| ROC | Rubeola (Measles) Ab, IgG,IgM, CSF | 90254-4 |
| Result ID | Test Result Name | Result LOINC Value |
|---|---|---|
| 5741 | Rubeola (Measles) Ab, IgG | 22501-1 |
| 5742 | Rubeola (Measles) Ab, IgM | In Process |
Interpretation
Detection of organism-specific antibodies in the cerebrospinal fluid (CSF) may suggest central nervous system infection. However, these results are unable to distinguish between intrathecal antibodies and serum antibodies introduced into the CSF at the time of lumbar puncture or from a breakdown in the blood-brain barrier. The results should be interpreted with other laboratory and clinical data prior to a diagnosis of central nervous system infection.
Patients with subacute sclerosing panencephalitis have serum antibody titers that are 10 to 100 times higher than those seen in late convalescent-phase sera. More importantly, there is pronounced local production of oligoclonal measles virus antibodies in the central nervous system.
Clinical Reference
1. Gascon GG: Subacute sclerosing panencephalitis. Semin Pediatr Neurol. 1996 Dec;3(4):260-269
2. Gershon AA: Measles virus (Rubeola). In: Bennett JE, Dolin R, Blaser MJ, eds. Mandell, Douglas, and Bennett's Principles and Practice of Infectious Diseases. 9th ed. Elsevier; 2020:2110-2116
Report Available
1 to 4 daysMethod Name
Immunofluorescence Assay (IFA)
Forms
If not ordering electronically, complete, print, and send Infectious Disease Serology Test Request (T916) with the specimen.