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Test Code RBR Retinol-Binding Protein, Random, Urine


Specimen Required


Container/Tube: Plastic, 5-mL tube

Specimen Volume: 5 mL

Collection Instructions:

1. Collect a random urine specimen.

2. No preservative.


Useful For

Assessing renal tubular injury or dysfunction using random urine collections

 

Screening for other tubular abnormalities

 

Detecting chronic asymptomatic renal tubular dysfunction.(2)

Profile Information

Test ID Reporting Name Available Separately Always Performed
CRETR Creatinine, Random, U Yes, (Order RCTUR) Yes
RBPR Retinol-Binding Protein, Random, U No Yes

Method Name

CRETR: Enzymatic Colorimetric Assay

RBPR: Immunonephelometry

Reporting Name

Retinol-Binding Protein, Random, U

Specimen Type

Urine

Specimen Minimum Volume

1 mL

Specimen Stability Information

Specimen Type Temperature Time Special Container
Urine Refrigerated (preferred) 7 days
  Frozen  7 days

Reference Values

≥18 years: <190 mcg/g creatinine

Reference values have not been established for patients that are less than 18 years.

Interpretation

Retinol-binding protein values above the reference values may be indicative of a proximal tubular dysfunction.

Clinical Reference

1. Kirsztajn GM, Nishida SK, Silva MS, Ajzen H, Moura LA, Bereira AB. Urinary retinol-binding protein as a prognostic marker in glomerulopathies. Nephron. 2002;90(4):424-431. doi:10.1159/000054730

2. Norden AG, Scheinman SJ, Deschodt-Lanckman MM, et al. Tubular proteinuria defined by a study of Dent's (CLCN5 mutation) and other tubular diseases. Kidney Int. 2000;57(1):240-249. doi:10.1046/j.1523-1755.2000.00847.x

3. Lamb EJ, Jones GJD. Kidney function tests. In: Rifai N, Horvath AR, Wittwer CT, eds. Tietz Textbook of Clinical Chemistry and Molecular Diagnostics. 6th ed. Elsevier; 2018:470-517

Day(s) Performed

Monday, Wednesday, Friday

Report Available

1 to 4 days

Performing Laboratory

Mayo Clinic Laboratories in Rochester

Test Classification

This test was developed and its performance characteristics determined by Mayo Clinic in a manner consistent with CLIA requirements. It has not been cleared or approved by the US Food and Drug Administration.

CPT Code Information

83883-Retinol -Binding Protein, Random, U

82570-Creatinine, Random, U

LOINC Code Information

Test ID Test Order Name Order LOINC Value
RBR Retinol-Binding Protein, Random, U 96401-5

 

Result ID Test Result Name Result LOINC Value
RBO1 Retinol-Binding Protein, Random, U 33782-4
CRETR Creatinine, Random, U 2161-8
RBPCR RBP/Creat Ratio 96402-3

Forms

If not ordering electronically, complete, print, and send a Renal Diagnostics Test Request (T830) with the specimen.