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Test Code RALB1 Albumin, Random, Urine


Specimen Required


Only orderable as part of a profile. For more information see:

-ALBR / Albumin, Random, Urine

-RALB / Albumin, Random, Urine.

 

Supplies: Sarstedt 5 mL Aliquot Tube (T914)

Specimen Volume: 5 mL

Collection Instructions:

1. Collect a random urine specimen.

2. No preservative.


Useful For

Assessing the potential for early onset of nephropathy in diabetic patients using random urine specimens

Method Name

Only orderable as part of a profile. For more information see:

-ALBR / Albumin, Random, Urine

-RALB / Albumin, Random, Urine.

  

Immunoturbidity

Reporting Name

Albumin, Random, U

Specimen Type

Urine

Specimen Minimum Volume

1 mL

Specimen Stability Information

Specimen Type Temperature Time Special Container
Urine Refrigerated (preferred) 7 days
  Ambient  7 days
  Frozen  7 days

Reference Values

Only orderable as part of a profile. For more information see:

-ALBR / Albumin, Random, Urine

-RALB / Albumin, Random, Urine.

 

Males: <17 mg/g creatinine

Females: <25 mg/g creatinine

Interpretation

In random urine specimens, normal urinary albumin excretion is below 17 mg/g creatinine for males and below 25 mg/g creatinine for females.(3)

 

Microalbuminuria is defined as an albumin:creatinine ratio of 17 to 299 for males and 25 to 299 for females.

 

A ratio of albumin:creatinine of 300 or higher is indicative of overt proteinuria.

 

Due to biologic variability, positive results should be confirmed by a second, first-morning random or 24-hour timed urine specimen. If there is discrepancy, a third specimen is recommended. When 2 out of 3 results are in the microalbuminuria range, this is evidence for incipient nephropathy and warrants increased efforts at glucose control, blood pressure control, and institution of therapy with an angiotensin-converting-enzyme (ACE) inhibitor (if the patient can tolerate it).

Clinical Reference

1. Bennett PH, Haffner S, Kasiske BL, et al: Screening and management of microalbuminuria in patients with diabetes mellitus: recommendations to the Scientific Advisory Board of the National Kidney Foundation from an ad hoc committee of the Council on Diabetes Mellitus of the National Kidney Foundation. Am J Kidney Dis. 1995 Jan;25:107-112. doi: 10.1016/0272-6386(95)90636-3

2. Krolewski AS, Laffel LM, Krolewski M, Quinn M, Warram JH: Glycosylated hemoglobin and the risk of microalbuminuria in patients with insulin-dependent diabetes mellitus. N Engl J Med. 1995 May 11;332:1251-1255. doi: 10.1056/NEJM199505113321902

3. Zelmanovitz T, Gross JL, Oliveira JR, Paggi A, Tatsch M, Azevedo MJ: The receiver operating characteristics curve in the evaluation of a random urine specimen as a screening test for diabetic nephropathy. Diabetes Care. 1997 April;20:516-519. doi: 10.2337/diacare.20.4.516

4. Miller GW, Bruns DE, Hortin GL, et al: Current issues in measurement and reporting of urinary albumin excretion. Clin Chem 2009 Jan;55(1):24-38. doi: 10.1373/clinchem.2008.106567

5. Lamb EJ, Jones GRD: Kidney functions tests. In: Rifai N, Horvath AR, Wittwer CT, eds. Tietz Textbook of Clinical Chemistry and Molecular Diagnostics. 6th ed. Elsevier; 2018:480-488

6. Sacks DB: Diabetes mellitus. In: Rifai N, Horvath AR, Wittwer CT, eds. Tietz Textbook of Clinical Chemistry and Molecular Diagnostics. 6th ed. In: Elsevier; 2018:1197-1199

Day(s) Performed

Monday through Sunday

Report Available

1 day

Performing Laboratory

Mayo Clinic Laboratories in Rochester

Test Classification

This test has been modified from the manufacturer's instructions. Its performance characteristics were determined by Mayo Clinic in a manner consistent with CLIA requirements. This test has not been cleared or approved by the US Food and Drug Administration.

CPT Code Information

82043

LOINC Code Information

Test ID Test Order Name Order LOINC Value
RALB1 Albumin, Random, U 9318-7

 

Result ID Test Result Name Result LOINC Value
RALB1 Albumin, Random, U 89999-7