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Test Code PTP Porphyrins, Total, Plasma

Important Note

  • Split immediately
  • Aliquot in Amber vial
  • Refrigerate 
  • PROTECT FROM LIGHT

Reporting Name

Porphyrins, Total, P

Useful For

Monitoring treatment of patients with porphyria cutanea tarda

Reflex Tests

Test ID Reporting Name Available Separately Always Performed
PFP Porphyrins, Fractionation, P No No

Testing Algorithm

If total porphyrins are above 1.0 mcg/dL, then porphyrin fractionation will be performed at an additional charge.

 

The following algorithms are available:

-Porphyria (Acute) Testing Algorithm

-Porphyria (Cutaneous) Testing Algorithm

Performing Laboratory

Mayo Clinic Laboratories in Rochester

Specimen Type

Plasma


Shipping Instructions


Ship specimen in amber vial to protect from light.



Necessary Information


Include a list of medications the patient is currently taking.



Specimen Required


Patient Preparation: Patient must not consume any alcohol for 24 hours before specimen collection.

Supplies: Amber Frosted Tube, 5 mL (T915)

Collection Container/Tube:

Preferred: Green top (sodium or lithium heparin)

Acceptable: Lavender top (EDTA)

Submission Container/Tube: Amber vial

Specimen Volume: 3 mL

Collection Instructions:

1. Centrifuge specimen and aliquot plasma into amber vial.

2. Send plasma frozen.


Specimen Minimum Volume

1 mL

Specimen Stability Information

Specimen Type Temperature Time Special Container
Plasma Frozen 14 days LIGHT PROTECTED

Reference Values

≤1.0 mcg/dL

Day(s) Performed

Monday through Friday

Test Classification

This test was developed and its performance characteristics determined by Mayo Clinic in a manner consistent with CLIA requirements. It has not been cleared or approved by the US Food and Drug Administration.

CPT Code Information

84311-Porphyrins, total

82542-Porphyrins, fractionation (if appropriate)

LOINC Code Information

Test ID Test Order Name Order LOINC Value
PTP Porphyrins, Total, P 2815-9

 

Result ID Test Result Name Result LOINC Value
8731 Porphyrins, Total, P 2815-9
34252 Reviewed By 18771-6
33869 Interpretation 59462-2

Interpretation

Abnormal results are reported with a detailed interpretation that may include an overview of the results and their significance, a correlation to available clinical information provided with the specimen, differential diagnosis, recommendations for additional testing when indicated and available, and a phone number to reach one of the laboratory directors in case the referring physician has additional questions.

Report Available

2 to 4 days

Clinical Reference

1. Tortorelli S, Kloke K, Raymond K. Disorders of porphyrin metabolism. In: Dietzen DJ, Bennett MJ, Wong EDD, eds. Biochemical and Molecular Basis of Pediatric Disease. 4th ed. AACC Press; 2010:307-324

2. Anderson KE, Sassa S, Bishop DF, Desnick RJ. Disorders of heme biosynthesis: X-Linked sideroblastic anemia and the porphyrias. In: Valle DL, Antonarakis S, Ballabio A, Beaudet AL, Mitchell GA, eds. The Online Metabolic and Molecular Bases of Inherited Disease. McGraw-Hill; 2019. Accessed September 6, 2024. Available at https://ommbid.mhmedical.com/content.aspx?sectionid=225540906&bookid=2709

3. Weiss Y, Chen B, Yasuda M, Nazarenko I, Anderson KE, Desnick RJ. Porphyria cutanea tarda and hepatoerythropoietic porphyria: Identification of 19 novel uroporphyrinogen III decarboxylase mutations. Mol Genet Metab. 2019;128(3):363-366. doi:10.1016/j.ymgme.2018.11.013

4. Phillips JD. Heme biosynthesis and the porphyrias. Mol Genet Metab. 2019;128(3):164-177. doi:10.1016/j.ymgme.2019.04.008

Method Name

PTP: Extraction and Scanning Spectrofluorometry

PFP: High-Performance Liquid Chromatography (HPLC)