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Test Code POWV Powassan Virus, IgM, Enzyme-Linked Immunosorbent Assay, Serum


Ordering Guidance


For patients with less than 7 days of symptoms, the recommended testing is molecular analysis for detection of Powassan virus (POWV) RNA. Contact either a local Public Health Laboratory or the Centers for Disease Control and Prevention.



Specimen Required


Supplies: Sarstedt 5 mL Aliquot Tube (T914)

Collection Container/Tube:

Preferred: Serum gel

Acceptable: Red top

Submission Container/Tube: Plastic vial

Specimen Volume: 0.6 mL

Collection Instructions: Centrifuge and aliquot serum into a plastic vial.


Useful For

Diagnosis of Powassan virus infection.

 

This test should not be used as a screening procedure for the general population.

 

This test should not be used as a "test of cure."

Method Name

Enzyme-Linked Immunosorbent Assay (ELISA)

Reporting Name

Powassan Virus, IgM, ELISA, S

Specimen Type

Serum

Specimen Minimum Volume

0.5 mL

Specimen Stability Information

Specimen Type Temperature Time Special Container
Serum Refrigerated (preferred) 14 days
  Frozen  30 days

Reference Values

Negative

Reference values apply to all ages.

Interpretation

Negative:

No antibodies to Powassan virus detected. Negative results may occur in samples collected too soon following infection, prior to the development of a robust immune response, or in immunocompromised patients.

 

Positive:

Antibodies to Powassan virus detected. Confirmatory testing through a local public health laboratory and/or the Centers for Disease Control and Prevention is recommended. False positive results may occur in patients with current or prior infection with other flaviviruses (West Nile virus, Zika virus, dengue virus, etc).

Clinical Reference

1. Centers for Disease Control and Prevention, National Center for Emerging and Zoonotic Infectious Diseases (NCEZID), Division of Vector-Borne Diseases (DVBD): Powassan virus disease. CDC; Updated January 10, 2019. Available at www.cdc.gov/ticks/tickbornediseases/powassan.html

2. Kemenesi G, Banyai K: Tick-borne Flaviviruses, with a focus on Powassan virus. Clinical Microbiology Reviews. 2019;32(1):e00106-00117

Day(s) Performed

Tuesday, Thursday

Report Available

Same day/1 to 4 days

Performing Laboratory

Mayo Clinic Laboratories in Rochester

Test Classification

This test was developed and its performance characteristics determined by Mayo Clinic in a manner consistent with CLIA requirements. It has not been cleared or approved by the US Food and Drug Administration.

CPT Code Information

86790

LOINC Code Information

Test ID Test Order Name Order LOINC Value
POWV Powassan Virus, IgM, ELISA, S 29855-4

 

Result ID Test Result Name Result LOINC Value
POWV Powassan Virus, IgM, ELISA, S 29855-4

Testing Algorithm

For information see the following:

-Meningitis/Encephalitis Panel Algorithm

-Acute Tickborne Disease Testing Algorithm

Forms

If not ordering electronically, complete, print, and send Infectious Disease Serology Test Request (T916) with the specimen.