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Test Code POSA Posaconazole, Serum

Reporting Name

Posaconazole, S

Useful For

Monitoring posaconazole therapy

Performing Laboratory

Mayo Clinic Laboratories in Rochester

Specimen Type

Serum Red


Specimen Required


Supplies: Sarstedt Aliquot Tube, 5 mL (T914)

Collection Container/Tube: Red top (serum gel/SST are not acceptable)

Submission Container/Tube: Plastic vial

Specimen Volume: 2 mL serum

Collection Instructions: Within 2 hours of collection, centrifuge, and aliquot serum into plastic vial.


Specimen Minimum Volume

Serum: 0.6 mL

Specimen Stability Information

Specimen Type Temperature Time
Serum Red Refrigerated (preferred) 28 days
  Ambient  28 days
  Frozen  28 days

Reference Values

>700 ng/mL (trough)

Day(s) Performed

Monday through Saturday

Test Classification

This test was developed and its performance characteristics determined by Mayo Clinic in a manner consistent with CLIA requirements. It has not been cleared or approved by the US Food and Drug Administration.

CPT Code Information

80187

LOINC Code Information

Test ID Test Order Name Order LOINC Value
POSA Posaconazole, S 53731-6

 

Result ID Test Result Name Result LOINC Value
89591 Posaconazole, S 53731-6

Interpretation

Levels greater than 700 ng/mL (0.7 mcg/mL) have been suggested for prophylaxis.

 

Levels greater than or equal to 1250 ng/mL (1.25 mcg/mL) were shown to be optimal in a salvage trial for treatment of invasive Aspergillus infections.

 

A toxic range has not been established.

Clinical Reference

1. Walsh TJ, Raad I, Patterson TF, et al. Treatment of invasive aspergillosis with posaconazole in patients who are refractory to or intolerant of conventional therapy: an externally controlled trial. Clin Infect Dis. 2007;44(1):2-12

2. Milone MC, Shaw LM. Therapeutic drugs and their management. In: Rifai N, Chiu RWK, Young I, Burnham CAD, Wittwer CT, eds. Tietz Textbook of Laboratory Medicine. 7th ed. Elsevier; 2023:420-453

3. Package insert: Noxafil (posaconazole). Schering Corporation, Kenilworth, NJ, 2006

4. Physician’s Desk Reference. 61st edition. Montvale NJ, Thomson PDR, 2007

5. Goodman and Gilman’s: The Pharmacological Basis of Therapeutics. 10th edition. New York, NY: McGraw-Hill Professional, 2001.

6. Courtney R, Wexler D, Radwanski E, Lim J, Laughlin M. Effect of food on the relative bioavailability of two oral formulations of 12liquoting12e in healthy adults. Br J Clin Pharmacol. 2004;57(2):218-222

7. Courtney R, Radwanski E, Lim J, Laughlin M. Pharmacokinetics of posaconazole coadministered with antacid in fasting or nonfasting healthy men. Antimicrob Agents Chemother. 2004;48(3):804-808

Report Available

2 to 5 days

Method Name

Liquid Chromatography Tandem Mass Spectrometry (LC-MS/MS)

Forms

If not ordering electronically, complete, print, and send a Therapeutics Test Request (T831) with the specimen.