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Test Code PGN Pregabalin, Serum

Useful For

Monitoring serum pregabalin (Lyrica) concentrations, assessing compliance, and adjusting dosage in patients

Method Name

Liquid Chromatography Tandem Mass Spectrometry (LC-MS/MS)

Reporting Name

Pregabalin, S

Specimen Type

Serum


Specimen Required


Supplies: Sarstedt Aliquot Tube, 5 mL (T914)

Collection Container/Tube: Red top

Submission Container/Tube: Plastic vial

Specimen Volume: 1 mL

Collection Instructions:

1. Collect specimen immediately before next scheduled dose.

2. Within 2 hours of collection, centrifuge, and aliquot serum into a plastic vial.


Specimen Minimum Volume

0.5 mL

Specimen Stability Information

Specimen Type Temperature Time Special Container
Serum Refrigerated (preferred) 28 days
  Ambient  28 days
  Frozen  28 days

Reference Values

2.0-5.0 mcg/mL

Interpretation

The serum concentration should be interpreted in the context of the patient's clinical response and other clinical tests. This may provide useful information for patients showing poor response, noncompliance, or adverse effects. Toxicity can occur with concentrations greater than or equal to 10 mcg/mL.

Clinical Reference

1. Baselt R: Disposition of Toxic Drugs and Chemicals in Man. 10th ed. Biomedical Publications; 2014

2. Hiemke C, Bergemann N, Clement HW, et al. Consensus guidelines for therapeutic drug monitoring in neuropsychopharmacology: Update 2017. Pharmacopsychiatry, 2018;51(1-02):9-62

Report Available

2 to 7 days

Performing Laboratory

Mayo Clinic Laboratories in Rochester

Test Classification

This test was developed and its performance characteristics determined by Mayo Clinic in a manner consistent with CLIA requirements. It has not been cleared or approved by the US Food and Drug Administration.

CPT Code Information

80299

LOINC Code Information

Test ID Test Order Name Order LOINC Value
PGN Pregabalin, S 47414-8

 

Result ID Test Result Name Result LOINC Value
65119 Pregabalin, S 47414-8

Day(s) Performed

Monday

Forms

If not ordering electronically, complete, print, and send a Therapeutics Test Request (T831) with the specimen.