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Test Code PETNU Phosphoethanolamine, Quantitative, Random, Urine


Necessary Information


1. Patient's age is required.

2. Include family history, clinical condition (asymptomatic or acute episode), diet, and drug therapy information.



Specimen Required


Supplies: Urine Tubes, 10 mL (T068)

Container/Tube: Clean plastic urine tube

Specimen Volume: 2 mL

Collection Instructions:

1. Collect a random urine specimen.

2. No preservative.


Useful For

To aid in the diagnosis of hypophosphatasia, especially in the setting of low alkaline phosphatase, bone fractures, and early tooth loss

 

Monitoring of affected individuals on therapy

Method Name

Liquid Chromatography Tandem Mass Spectrometry (LC-MS/MS)

This test is covered by patents held by Quest Diagnostics

Reporting Name

Phosphoethanolamine, QN, Random, U

Specimen Type

Urine

Specimen Minimum Volume

1 mL

Specimen Stability Information

Specimen Type Temperature Time
Urine Frozen (preferred) 70 days
  Refrigerated  14 days

Reference Values

≤12 months: 15-341 nmol/mg creatinine

13-35 months: 33-342 nmol/mg creatinine

3-6 years: 19-164 nmol/mg creatinine

7-8 years: 12-118 nmol/mg creatinine

9-17 years: <88 nmol/mg creatinine

≥18 years: <48 nmol/mg creatinine

An interpretative report will be provided.

Interpretation

Elevations of phosphoethanolamine may be indicative of hypophosphatasia.

 

Abnormal results should be confirmed using ALKP / Alkaline Phosphatase, Total and Isoenzymes, Serum and molecular genetic testing of ALPL (CGPH / Custom Gene Panel, Hereditary, Next-Generation Sequencing, Varies; specify Gene List ID: RENAL-D5DR9D).

Clinical Reference

1. Shajani-Yi Z, Ayala-Lopez N, Black M, Dahir KM. Urine phosphoethanolamine is a specific biomarker for hypophosphatasia in adults. Bone. 2022;163:116504

2. Dahir KM, Nunes ME. Hypophosphatasia. In: Adam MP, Feldman J, Mirzaa GM, et al, eds. GeneReviews [Internet]. University of Washington, Seattle; 2007. Accessed May 22, 2026. Available at www.ncbi.nlm.nih.gov/sites/books/NBK1150/

3. Seefried L, Genest F, Petryk A, Veith M. Effects of asfotase alfa in adults with pediatric-onset hypophosphatasia over 24 months of treatment. Bone. 2023;175:116856. doi:10.1016/j.bone.2023.116856

Day(s) Performed

Tuesday

Report Available

3 to 9 days

Performing Laboratory

Mayo Clinic Laboratories in Rochester

Test Classification

This test was developed and its performance characteristics determined by Mayo Clinic in a manner consistent with CLIA requirements. It has not been cleared or approved by the US Food and Drug Administration.

CPT Code Information

82131

LOINC Code Information

Test ID Test Order Name Order LOINC Value
PETNU Phosphoethanolamine, QN, Random, U In Process

 

Result ID Test Result Name Result LOINC Value
623432 Interpretation 59462-2
623430 Phosphoethanolamine 28604-7
623431 Reviewed By 18771-6