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HelpTest Code PACP Prostatic Acid Phosphatase, Serum
Reporting Name
Prostatic Acid Phosphatase, SUseful For
Aiding in predicting recurrence after radical prostatectomy for clinically localized prostate cancer
Following response to androgen ablation therapy, when used in conjunction with prostate-specific antigen
Performing Laboratory
Mayo Clinic Laboratories in Rochester
Specimen Type
SerumSpecimen Required
Patient Preparation: For 12 hours before specimen collection, do not take multivitamins or dietary supplements containing biotin (vitamin B7), which is commonly found in hair, skin, and nail supplements and multivitamins.
Collection Container/Tube:
Preferred: Red top
Acceptable: Serum gel
Submission Container/Tube: Plastic vial
Specimen Volume: 1 mL
Collection Instructions: Centrifuge and aliquot serum into a plastic vial.
Specimen Minimum Volume
0.4 mL
Specimen Stability Information
| Specimen Type | Temperature | Time | Special Container |
|---|---|---|---|
| Serum | Refrigerated (preferred) | 7 days | |
| Frozen | 180 days |
Reference Values
≤2.1 ng/mL
Day(s) Performed
Monday, Wednesday, Friday
Test Classification
This test has been cleared, approved, or is exempt by the US Food and Drug Administration and is used per manufacturer's instructions. Performance characteristics were verified by Mayo Clinic in a manner consistent with CLIA requirements.CPT Code Information
84066
LOINC Code Information
| Test ID | Test Order Name | Order LOINC Value |
|---|---|---|
| PACP | Prostatic Acid Phosphatase, S | 20420-6 |
| Result ID | Test Result Name | Result LOINC Value |
|---|---|---|
| PACP | Prostatic Acid Phosphatase, S | 20420-6 |
Interpretation
Prostatic acid phosphatase (PAP) levels above the reference range may indicate prostate cancer but can be due to many other factors, see Cautions.
A rise in PAP levels in patients with known prostate cancer can indicate tumor progression or recurrence. However, there is considerable intra-subject biological variability, limiting the usefulness of this test.
Clinical Reference
1. Moul JW, Connelly RR, Perahia B, McLeod DG. The contemporary value of pretreatment prostatic acid phosphatase to predict pathological stage and recurrence in radical prostatectomy cases. J Urol. 1998;159:935-940
2. Beaver TR, Schultz AL, Fink LM, et al. Discordance between concentration of prostate-specific antigen and acid phosphatase in serum of patients with adenocarcinoma of the prostate. Clin Chem. 1988;34:1524
3. Velonas VM, Woo HH, dos Remedios CG, Assinder SJ. Current status of biomarkers for prostate cancer. Int J Mol Sci. 2013;14(6):11034-60. doi:10.3390/ijms140611034
4. Kong HY, Byun J. Emerging roles of human prostatic acid phosphatase. Biomol Ther (Seoul). 2013;21(1):10-20. doi: 10.4062/biomolther.2012.095
Report Available
1 to 3 daysMethod Name
Automated Chemiluminescent Immunometric Assay