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Test Code PA Procainamide and N-Acetylprocainamide, Serum


Specimen Required


Supplies: Sarstedt Aliquot Tube, 5 mL (T914)

Collection Container/Tube:

Preferred: Serum gel

Acceptable: Red top

Submission Container/Tube: Plastic vial

Specimen Volume: 0.5 mL Serum

Collection Instructions:

1. Within 2 hours of collection, centrifuge the specimen.

2. For serum gel tubes, plasma may sit on gel refrigerated or be aliquoted into a plastic vial.

3. For red top tubes, aliquot serum immediately into a plastic vial.


Useful For

Monitoring therapy with procainamide

 

Assessing compliance

 

Evaluating procainamide toxicity

Method Name

Homogeneous Enzyme Immunoassay

Reporting Name

Procainamide and NAPA, S

Specimen Type

Serum

Specimen Minimum Volume

Serum: 0.25 mL

Specimen Stability Information

Specimen Type Temperature Time
Serum Frozen (preferred) 14 days
  Refrigerated  7 days
  Ambient  24 hours

Reference Values

Procainamide

Therapeutic: 4.0-10.0 mcg/mL

Critical value: >12.0 mcg/mL

 

N-acetylprocainamide

Therapeutic: 12.0-18.0 mcg/mL

Critical value: ≥40.0 mcg/mL

Interpretation

Administration of a dose of 50 mg/kg will usually yield the optimal trough concentration in the range of 4.0 to 10.0 mcg/mL for procainamide and 12.0 to 18.0 mcg/mL for N-acetylprocainamide.

Clinical Reference

1. Milone MC, Shaw LM. Chapter 42: Therapeutic drugs and their management. In: Rifai N, Chiu RWK, Young I, Burnham C-AD, Wittwer CT, eds. Tietz Textbook of Laboratory Medicine. 7th ed. Elsevier; 2023:420-453.e9

2. Brunton LL, Knollmann BC, eds. Goodman and Gilman's: The Pharmacological Basis of Therapeutics, 14th ed. McGraw-Hill Education, 2023

Day(s) Performed

Monday through Saturday

Report Available

Same day/1 to 2 days

Performing Laboratory

Mayo Clinic Laboratories in Rochester

Test Classification

This test has been cleared, approved, or is exempt by the US Food and Drug Administration and is used per manufacturer's instructions. Performance characteristics were verified by Mayo Clinic in a manner consistent with CLIA requirements.

CPT Code Information

80192

LOINC Code Information

Test ID Test Order Name Order LOINC Value
PA Procainamide and NAPA, S 3983-4

 

Result ID Test Result Name Result LOINC Value
8683 Procainamide, S 3982-6
2461 N-acetylprocainamide, S 3834-9
2462 Procainamide + NAPA 3983-4

Forms

If not ordering electronically, complete, print, and send 1 of the following forms with the specimen:

-Cardiovascular Test Request (T724)

-Therapeutics Test Request (T831)