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Test Code NUTHX Hazelnut-Food Components, IgE, Serum


Specimen Required


Only orderable as a reflex. For more information see NUTHR / Hazelnut-Food, IgE with Reflex to Hazelnut-Food Components, IgE, Serum.

 

Supplies: Sarstedt Aliquot Tube 5 mL (T914)

Container/Tube:

Preferred: Serum gel

Acceptable: Red top

Submission Container/Tube: Plastic vial

Specimen Volume: 1 mL Serum

Collection Instructions: Centrifuge and aliquot serum into a plastic vial.


Useful For

Evaluation of patients with suspected hazelnut-food allergy to one of 4 hazelnut-food components

Testing Algorithm

If the hazelnut-food specific total IgE is 0.10 kU/L or more, then testing for four hazelnut-food components (Cor a 1, Cor a 8, Cor a 9, Cor a 14) is performed at an additional charge.

Method Name

Only orderable as a reflex. For more information see NUTHR / Hazelnut-Food, IgE with Reflex to Hazelnut-Food Components, IgE, Serum.

 

Fluorescent Enzyme Immunoassay (FEIA)

Reporting Name

Hazelnut-Food Components, IgE, S

Specimen Type

Serum

Specimen Minimum Volume

Serum: 0.6 mL

Specimen Stability Information

Specimen Type Temperature Time
Serum Refrigerated (preferred) 14 days
  Frozen  90 days

Reference Values

Only orderable as a reflex. For more information see NUTHR / Hazelnut-Food, IgE with Reflex to Hazelnut-Food Components, IgE, Serum.

 

Class

IgE kU/L

Interpretation

0

<0.10

Negative

0/1

0.10-0.34

Borderline/equivocal

1

0.35-0.69

Equivocal

2

0.70-3.49

Positive

3

3.50-17.4

Positive

4

17.5-49.9

Strongly positive

5

50.0-99.9

Strongly positive

6

≥100

Strongly positive

Concentrations of 0.70 kU/L or more (class 2 and above) will flag as abnormally high.

Reference values apply to all ages.

Interpretation

When detectable total hazelnut-food IgE antibody is present (≥0.10 IgE kUa/L), additional specific component IgE antibody testing will be performed. If a potential specific allergenic hazelnut-food component IgE is detectable (≥0.10 IgE kUa/L), an interpretive report will be provided.

 

When the sample is negative for total hazelnut-food IgE antibody (<0.10 IgE kUa/L), further testing for specific hazelnut-food component IgE antibodies will not be performed. A negative IgE result for total cashew antibody may indicate a lack of sensitization to the potential hazelnut-food allergenic components.

Clinical Reference

1. Salo PM, Arbes SJ Jr, Jaramillo R, et al. Prevalence of allergic sensitization in the United States: results from the National Health and Nutrition Examination Survey (NHANES) 2005-2006. J Allergy Clin Immunol. 2014;134(2):350-359. doi:10.1016/j.jaci.2013.12.1071

2. Waserman S, Watson W. Food allergy. Allergy Asthma Clin Immunol. 2011;7 Suppl 1(Suppl 1):S7

3. Abrams EM, Sicherer SH. Diagnosis and management of food allergy. CMAJ. 2016;188(15):1087-1093. doi:10.1503/cmaj.160124

4. Weinberger T, Sicherer S. Current perspectives on tree nut allergy: a review. J Asthma Allergy. 2018;11:41-51. doi:10.2147/JAA.S141636

5. Lomas JM, Jarvinen KM. Managing nut-induced anaphylaxis: challenges and solutions. J Asthma Allergy. 2015;8:115-123. doi:10.2147/JAA.S89121

6. Maloney JM, Rudengren M, Ahlstedt S, Bock SA, Sampson HA. The use of serum-specific IgE measurements for the diagnosis of peanut, tree nut, and seed allergy. J Allergy Clin Immunol. 2008;122(1):145-151. doi:10.1016/j.jaci.2008.04.014

7. Sicherer SH, Burks AW, Sampson HA. Clinical features of acute allergic reactions to peanut and tree nuts in children. Pediatrics. 1998;102(1):e6. doi:10.1542/peds.102.1.e6

8. Crespo JF, James JM, Fernandez-Rodriguez C, Rodriguez J. Food allergy: nuts and tree nuts. Br J Nutr. 2006;96 Suppl 2:S95-S102. doi:10.1017/bjn20061869

9. Yang L, Clements S, Joks R. A retrospective study of peanut and tree nut allergy: Sensitization and correlations with clinical manifestations. Allergy Rhinol (Providence). Published online February 27, 2015. doi:10.2500/ar.20105.6.0108

10. Masthoff LJ, Hoff R, Verhoeckx KC, et al. A systematic review of the effect of thermal processing on the allergenicity of tree nuts. Allergy. 2013;68(8):983-993. doi:10.1111/all.12185

11. Ebo DG, Verweij MM, Sabato V, Hagendorens MM, Bridts CH, De Clerck LS. Hazelnut allergy: a multi-faced condition with demographic and geographic characteristics. Acta Clin Belg. 2012;67(5):317-321. doi:10.2143/ACB.67.5.2062683

12. Calamelli E, Trozzo A, Di Blasi E, Serra L, Bottau P. Hazelnut Allergy. Medicina (Kaunas). 2021;57(1):67. doi:10.3390/medicina57010067

13. Uotila R, Kukkonen AK, Pelkonen AS, Makela MJ. Cross-sensitization profiles of edible nuts in a birch-endemic area. Allergy. 2016;71(4):514-521. doi:10.1111/all.12826

14. Datema MR, van Ree R, Asero R, et al. Component-resolved diagnosis and beyond: Multivariable regression models to predict severity of hazelnut allergy. Allergy. 2018;73(3):549-559. doi:10.1111/all.13328

15. Hofmann C, Scheurer S, Rost K, et al. Cor a 1-reactive T cells and IgE are predominantly cross-reactive to Bet v 1 in patients with birch pollen-associated food allergy to hazelnut. J Allergy Clin Immunol. 2013;131(5):1384-92.e6. doi:10.1016/j.jaci.2012.10.037

16. Nilsson C, Berthold M, Mascialino B, Orme M, Sjolander S, Hamilton R. Allergen components in diagnosing childhood hazelnut allergy: Systematic literature review and meta-analysis. Pediatr Allergy Immunol. 2020;31(2):186-196. doi:10.1111/pai.13110

17. Inoue Y, Sato S, Takahashi K, et al. Component-resolved diagnostics can be useful for identifying hazelnut allergy in Japanese children. Allergol Int. 2020;69(2):239-245. doi:10.1016/j.alit.2019.10.001

18. Faber MA, De Graag M, Van Der Heijden C, et al. Cor a 14: missing link in the molecular diagnosis of hazelnut allergy?. Int Arch Allergy Immunol. 2014;164(3):200-206. doi:10.1159/000365050

19. Costa J, Mafra I, Carrapatoso I, Oliveira MB. Hazelnut Allergens: Molecular Characterization, Detection, and Clinical Relevance. Crit Rev Food Sci Nutr. 2016;56(15):2579-2605. doi:10.1080/10408398.2013.826173

20. Buyuktiryaki B, Cavkaytar O, Sahiner UM, et al. Cor a 14, Hazelnut-Specific IgE, and SPT as a Reliable Tool in Hazelnut Allergy Diagnosis in Eastern Mediterranean Children. J Allergy Clin Immunol Pract. 2016;4(2):265-72.e3. doi:10.1016/j.jaip.2015.12.012

21. Brough HA, Caubet JC, Mazon A, et al. Defining challenge-proven coexistent nut and sesame seed allergy: A prospective multicenter European study. J Allergy Clin Immunol. 2020;145(4):1231-1239. doi:10.1016/j.jaci.2019.09.036

22. Datema MR, Zuidmeer-Jongejan L, Asero R, et al. Hazelnut allergy across Europe dissected molecularly: A EuroPrevall outpatient clinic survey. J Allergy Clin Immunol. 2015;136(2):382-391. doi:10.1016/j.jaci.2014.12.1949

23. Masthoff LJ, van Hoffen E, Mattsson L, et al. Peanut allergy is common among hazelnut-sensitized subjects but is not primarily the result of IgE cross-reactivity. Allergy. 2015;70(3):265-274. doi:10.1111/all.12554

24. Bastiaan-Net S, Batstra MR, Aazamy N, et al. IgE cross-reactivity measurement of cashew nut, hazelnut and peanut using a novel IMMULITE inhibition method. Clin Chem Lab Med. 2020;58(11):1875-1883. doi:10.1515/cclm-2019-1083

25. Carraro S, Berardi M, Bozzetto S, Baraldi E, Zanconato S. COR a 14-specific IgE predicts symptomatic hazelnut allergy in children. Pediatr Allergy Immunol. 2016;27(3):322-324. doi:10.1111/pai.12526

26. Buyuktiryaki B, Cavkaytar O, Sahiner UM, et al. Cor a 14, Hazelnut-Specific IgE, and SPT as a Reliable Tool in Hazelnut Allergy Diagnosis in Eastern Mediterranean Children. J Allergy Clin Immunol Pract. 2016;4(2):265-72.e3. doi:10.1016/j.jaip.2015.12.012

27. Uotila R, Rontynen P, Pelkonen AS, Voutilainen H, Kaarina Kukkonen A, Makela MJ. For hazelnut allergy, component testing of Cor a 9 and Cor a 14 is relevant also in birch-endemic areas. Allergy. 2020;75(11):2977-2980. doi:10.1111/all.14430

Day(s) Performed

Monday through Friday

Report Available

Same day/1 to 3 days

Performing Laboratory

Mayo Clinic Laboratories in Rochester

Test Classification

This test has been cleared, approved, or is exempt by the US Food and Drug Administration and is used per manufacturer's instructions. Performance characteristics were verified by Mayo Clinic in a manner consistent with CLIA requirements.

CPT Code Information

86003

86008 x 3

LOINC Code Information

Test ID Test Order Name Order LOINC Value
NUTHX Hazelnut-Food Components, IgE, S 63486-5

 

Result ID Test Result Name Result LOINC Value
INUTH Hazelnut-Food IgE Ab Interpretation 69048-7
A1COR Cor a 1 (Hazelnut-Food), IgE, S 69421-6
A8COR Cor a 8 (Hazelnut-Food), IgE, S 58753-5
A9COR Cor a 9 (Hazelnut-Food), IgE, S 65765-0
A14CO Cor a 14 (Hazelnut-Food), IgE, S 81788-2