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HelpTest Code NUTHX Hazelnut-Food Components, IgE, Serum
Specimen Required
Only orderable as a reflex. For more information see NUTHR / Hazelnut-Food, IgE with Reflex to Hazelnut-Food Components, IgE, Serum.
Container/Tube:
Preferred: Serum gel
Acceptable: Red top
Submission Container/Tube: Plastic vial
Specimen Volume: 1 mL
Collection Instructions: Centrifuge and aliquot serum into a plastic vial.
Useful For
Evaluation of patients with suspected hazelnut-food allergy to one of 4 hazelnut-food components
Testing Algorithm
If hazelnut-food specific total IgE is 0.10 kU/L or more, then testing for four hazelnut-food components (Cor a 1, Cor a 8, Cor a 9, Cor a 14) is performed at an additional charge.
Method Name
Only orderable as a reflex. For more information see NUTHR / Hazelnut-Food, IgE with Reflex to Hazelnut-Food Components, IgE, Serum.
Fluorescent Enzyme Immunoassay (FEIA)
Reporting Name
Hazelnut-Food Components, IgE, SSpecimen Type
SerumSpecimen Minimum Volume
0.6 mL
Specimen Stability Information
| Specimen Type | Temperature | Time | Special Container |
|---|---|---|---|
| Serum | Refrigerated (preferred) | 14 days | |
| Frozen | 90 days |
Reference Values
Only orderable as a reflex. For more information see NUTHR / Hazelnut-Food, IgE with Reflex to Hazelnut-Food Components, IgE, Serum.
|
Class |
IgE kU/L |
Interpretation |
|
0 |
<0.10 |
Negative |
|
0/1 |
0.10-0.34 |
Borderline / Equivocal |
|
1 |
0.35-0.69 |
Equivocal |
|
2 |
0.70-3.49 |
Positive |
|
3 |
3.50-17.4 |
Positive |
|
4 |
17.5-49.9 |
Strongly positive |
|
5 |
50.0-99.9 |
Strongly positive |
|
6 |
≥100 |
Strongly positive |
Concentrations of 0.70 kU/L or more (class 2 and above) will flag as abnormally high.
Reference values apply to all ages.
Interpretation
When detectable total hazelnut-food IgE antibody is present (≥0.10 IgE kUa/L), additional specific component IgE antibody testing will be performed. If a potential specific allergenic hazelnut-food component IgE is detectable (≥0.10 IgE kUa/L), an interpretive report will be provided.
When the sample is negative for total hazelnut-food IgE antibody (<0.10 IgE kUa/L), further testing for specific hazelnut-food component IgE antibodies will not be performed. A negative IgE result for total cashew antibody may indicate a lack of sensitization to the potential hazelnut-food allergenic components.
Clinical Reference
1. Salo PM, Arbes SJ Jr, Jaramillo R, et al. Prevalence of allergic sensitization in the United States: results from the National Health and Nutrition Examination Survey (NHANES) 2005-2006. J Allergy Clin Immunol. 2014;134(2):350-359. doi: 10.1016/j.jaci.2013.12.1071
2. Waserman S, Watson W. Food allergy. Allergy Asthma & Clin Immuno.2011, 7 Suppl1 (Suppl 1):S7
3. Abrams EM, Sicherer SH. Diagnosis and management of food allergy. CMAJ. 2016;188(15):1087–1093
4. Weinberger T, Sicherer S. Current perspectives on tree nut allergy: a review. J Asthma Allergy. 2018;11:41–51
5. Lomas JM, Jarvinen KM. Managing nut-induced anaphylaxis: challenges and solutions. J Asthma Allergy. 2015;8:115–123
6. Maloney J, Rudengren M, Ahlstedt S, Bock SA, Sampson HA. The use of serum-specific IgE measurements for the diagnosis of peanut, tree nut, and seed allergy. J Allergy Clin Immunol. 2008;122(1):145-151
7. Sicherer SH, Burks AW, Sampson HA. Clinical features of acute allergic reactions to peanut and tree nuts in children. Pediatrics. 1998;102(1):e6
8. Crespo JF, James JM. Fernandez-Rodriguez C, Rodriguez J. Food allergy: Nuts and tree nuts. British J Nutrition. 2006;96 Suppl 2:S95-S102
9. Yang L, Clements S, Joks R. A retrospective study of peanut and tree nut allergy: Sensitization and correlations with clinical manifestations. Allergy Rhinol. 2015;doi:10.2500/ar.20105.6.0108
10. Masthoff L, Hoff R, Verhoeckx KC, et al. A systematic review of the effect of thermal processing on the allergenicity of tree nuts. Allergy 2013;68(8):983-993
11. Ebo DG, Verweij MM, Sabato V, Hagendorens MM, Bridts CH, De Clerck LS. Hazelnut allergy: A multi-faced condition with demographic and geographic characteristics. Acta clinica Belgica. 2012;67(5):317-321
12 .Calamelli E, Trozzo A, Di Blasi E, Serra L, Bottau P. Hazelnut allergy. Medicina (Kaunas). 2021;57(1):67
13. Uotila R, Kukkonen AK, Pelkonen AS, Makela MJ. Cross-sensitization profiles of edible nuts in a birch-endemic area. Allergy. 2016;71(4):514-521
14. Datema MR, van Ree R, Asero R, et al. Component-resolved diagnosis and beyond: Multivariable regression models to predict severity of hazelnut allergy. Allergy. 2018;73(3):549-559
15. Hofmann C, Scheurer S, Rost K, et al. Cor a 1-reactive T cells and IgE are predominantly cross-reactive to Bet v 1 in patients with birch pollen-associated food allergy to hazelnut. The J Allergy Clin Immunol. 2013;131(5):1384-1392.e6
16. Nilsson C, Berthold M, Mascialino B, Orme M, Sjölander S, Hamilton R. Allergen components in diagnosing childhood hazelnut allergy: Systematic literature review and meta-analysis. Pediatr Allergy Immunol. 2020;31(2):186-96.
17. Inoue Y, Sato S, Takahashi K, et al. Component-resolved diagnostics can be useful for identifying hazelnut allergy in Japanese children. Allergol Int. 2020;69(2):239-245
18. Faber MA, De Graag M, Van Der Heijden C, et al. Cor a 14: missing link in the molecular diagnosis of hazelnut allergy? Int Arch Allergy Immunol. 2014;164(3):200-206
19. Costa J, Mafra I, Carrapatoso I, Oliveira MB. Hazelnut allergens: Molecular characterization, detection, and clinical relevance. Crit Rev Food Sci Nutr. 2016;56(15):2579-2605
20. Buyuktiryaki B, Cavkaytar O, Sahiner UM, et al. Cor a 14, hazelnut-specific IgE, and SPT as a reliable tool in hazelnut allergy diagnosis in Eastern Mediterranean Children. J Allergy Clin Immunol Pract. 2016;4(2):265-72.e3
21. Brough HA, Caubet JC, Mazon A, et al. Defining challenge-proven coexistent nut and sesame seed allergy: A prospective multicenter European study. J Allergy Clin Immunol. 2020;145(4):1231-1239
22. Datema MR, Zuidmeer-Jongejan L, Asero R, et al. Hazelnut allergy across Europe dissected molecularly: A EuroPrevall outpatient clinic survey. J Allergy Clin Immunol. 2015;136(2):382-391
23. Masthoff LJ, van Hoffen E, Mattsson L, et al. Peanut allergy is common among hazelnut-sensitized subjects but is not primarily the result of IgE cross-reactivity. Allergy. 2015;70(3):265-274
24. Bastiaan-Net S, Batstra MR, Aazamy N, et al. IgE cross-reactivity measurement of cashew nut, hazelnut and peanut using a novel IMMULITE inhibition method. Clin Chem Lab Med. 2020;58(11):1875-1883
25. Carraro S, Berardi M, Bozzetto S, Baraldi E, Zanconato S. COR a 14-specific IgE predicts symptomatic hazelnut allergy in children. Pediatr Allergy Immunol. 2016;27(3):322-324
26. Buyuktiryaki B, Cavkaytar O, Sahiner UM, et al. Cor a 14, hazelnut-specific IgE, and SPT as a reliable tool in hazelnut allergy diagnosis in Eastern Mediterranean children. J Allergy Clin Immunol Pract. 2016;4(2):265-72.e3
27. Uotila R, Rontynen P, Pelkonen AS, Voutilainen H, Kaarina Kukkonen A, Makela MJ. For hazelnut allergy, component testing of Cor a 9 and Cor a 14 is relevant also in birch-endemic areas. Allergy. 2020;75(11):2977-2980
Day(s) Performed
Monday through Friday
Report Available
Same day/1 to 3 daysPerforming Laboratory
Mayo Clinic Laboratories in Rochester
Test Classification
This test has been cleared, approved, or is exempt by the US Food and Drug Administration and is used per manufacturer's instructions. Performance characteristics were verified by Mayo Clinic in a manner consistent with CLIA requirements.CPT Code Information
86003
86008 x 3
LOINC Code Information
| Test ID | Test Order Name | Order LOINC Value |
|---|---|---|
| NUTHX | Hazelnut-Food Components, IgE, S | 63486-5 |
| Result ID | Test Result Name | Result LOINC Value |
|---|---|---|
| INUTH | Hazelnut-Food IgE Ab Interpretation | 69048-7 |
| A1COR | Cor a 1 (Hazelnut-Food), IgE, S | 69421-6 |
| A8COR | Cor a 8 (Hazelnut-Food), IgE, S | 58753-5 |
| A9COR | Cor a 9 (Hazelnut-Food), IgE, S | 65765-0 |
| A14CO | Cor a 14 (Hazelnut-Food), IgE, S | 81788-2 |