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Test Code NIU Nickel, 24 Hour, Urine

Reporting Name

Nickel, 24 Hr, U

Useful For

Preferred test for biomonitoring patients for nickel exposure to minimize any potential diurnal variation

Performing Laboratory

Mayo Clinic Laboratories in Rochester

Specimen Type

Urine


Ordering Guidance


This test is preferred for the determination of nickel exposure, but serum concentrations can be used to verify an elevated urine concentration. For more information see NIS / Nickel, Serum.



Necessary Information


24-Hour volume (in milliliters) is required.



Specimen Required


Patient Preparation: High concentrations of gadolinium and iodine are known to interfere with most metal tests. If gadolinium- or iodine-containing contrast media has been administered, a specimen should not be collected for 96 hours.

Supplies: Urine Tubes, 10 mL (T068)

Container/Tube: Plastic, 10-mL urine tube or clean, plastic aliquot container with no metal cap or glued insert

Specimen Volume: 0.5 mL

Collection Instructions:

1. Collect urine for 24 hours.

2. Refrigerate specimen within 4 hours of completion of 24-hour collection.

See Metals Analysis Specimen Collection and Transport for complete instructions.

Additional Information: See Urine Preservatives-Collection and Transportation for 24-Hour Urine Specimens for multiple collections.


Specimen Minimum Volume

0.3 mL

Specimen Stability Information

Specimen Type Temperature Time Special Container
Urine Refrigerated (preferred) 28 days
  Ambient  28 days
  Frozen  28 days

Reference Values

0-17 years: not established

≥18 years: <6.0 mcg/24h

Day(s) Performed

Thursday

Test Classification

This test was developed and its performance characteristics determined by Mayo Clinic in a manner consistent with CLIA requirements. It has not been cleared or approved by the US Food and Drug Administration.

CPT Code Information

83885

LOINC Code Information

Test ID Test Order Name Order LOINC Value
NIU Nickel, 24 Hr, U 5705-9

 

Result ID Test Result Name Result LOINC Value
8626 Nickel, 24 Hr, U 5705-9
TM18 Collection Duration 13362-9
VL30 Urine Volume 3167-4

Interpretation

Values of 6.0 mcg/24-hour specimen and higher represent possible environmental or occupational exposure.

 

Hypernickelemia, in the absence of exposure, may be an incidental finding or could be due to specimen contamination.

Clinical Reference

1. Moreno ME, Acosta-Saavedra LC, Mez-Figueroa D, et al: Biomonitoring of metal in children living in a mine tailings zone in Southern Mexico: A pilot study. Int J Hyg Environ Health. 2010 Jul;213(4):252-258. doi: 10.1016/j.ijheh.2010.03.005

2. Schulz C, Angerer J, Ewers U, Heudorf U, Wilhelm M, Human Biomonitoring Commission of the German Federal Environment Agency: Revised and new reference values for environmental pollutants in urine or blood of children in Germany derived from the German Environmental Survey on Children 2003-2006 (GerES IV). Int J Hyg Environ Health. 2009 Nov;212(6):637-647. doi: 10.1016/j.ijheh.2009.05.003

3. US Department of Health and Human Services: Toxicological profile for nickel. Agency for Toxic Substances and Disease Registry. 2005 Accessed: March 2020. Available at: www.atsdr.cdc.gov/ToxProfiles/tp15.pdf

4. Rifai N, Horvath AR, Wittwer CT, eds: Tietz Textbook of Clinical Chemistry and Molecular Diagnostics. 6th ed. Elsevier; 2018

5. Zambelli B, Ciurli S: Nickel and human health. In: Sigel A, Sigel H, Sigel R, eds. Interrelations between Essential Metal Ions and Human Diseases. Metal Ions in Life Sciences. Vol 13. Springer, Dordrecht; 2013:321-357

Report Available

2 to 8 days

Method Name

Inductively Coupled Plasma-Mass Spectrometry (ICP-MS)