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Test Code NF4FS Neurofascin-155 IgG4, Flow Cytometry, Serum


Specimen Required


Only orderable as part of a profile. For more information see:

-CIDP / Chronic Inflammatory Demyelinating Polyradiculoneuropathy/Nodopathy Evaluation, Serum

-DMNES / Peripheral Nervous System Demyelinating Neuropathy, Autoimmune Evaluation, Serum


Useful For

Evaluating patients with an underlying demyelinating neuropathy

 

Diagnosis of a neurofascin-155 IgG4 mediated neuropathy

Method Name

Only orderable as part of a profile. For more information see:

-CIDP / Chronic Inflammatory Demyelinating Polyradiculoneuropathy/Nodopathy Evaluation, Serum

-DMNES / Peripheral Nervous System Demyelinating Neuropathy, Autoimmune Evaluation, Serum

 

Flow Cytometry (FCM)

Reporting Name

Neurofascin-155 IgG4, S

Specimen Type

Serum

Specimen Minimum Volume

See Specimen Required

Specimen Stability Information

Specimen Type Temperature Time Special Container
Serum Refrigerated (preferred) 28 days
  Frozen  28 days
  Ambient  72 hours

Reference Values

Only orderable as part of a profile. For more information see:

-CIDP / Chronic Inflammatory Demyelinating Polyradiculoneuropathy/Nodopathy Evaluation, Serum

-DMNES / Peripheral Nervous System Demyelinating Neuropathy, Autoimmune Evaluation, Serum

 

Negative

Interpretation

A positive result is consistent with a neurofascin-155 IgG4 mediated demyelinating neuropathy.

Clinical Reference

1. Ogata H, Yamasaki R, Hiwatashi A, et al. Characterization of IgG4 anti-neurofascin 155 antibody-positive polyneuropathy. Ann Clin Transl Neurol. 2015;2(10):960-971

2. Cortese A, Lombardi R, Briani C, et al. Antibodies to neurofascin, contactin-1, and contactin-associated protein 1 in CIDP: Clinical relevance of IgG isotype. Neurol Neuroimmunol Neuroinflamm. 2020;7(1):e639

3. Querol L, Nogales-Gadea G, Rojas-Garcia R, et al. Neurofascin IgG4 antibodies in CIDP associate with disabling tremor and poor response to IVIg. Neurology. 2014;82(10):879-886

Day(s) Performed

Monday, Friday

Report Available

5 to 8 days

Performing Laboratory

Mayo Clinic Laboratories in Rochester

Test Classification

This test was developed and its performance characteristics determined by Mayo Clinic in a manner consistent with CLIA requirements. It has not been cleared or approved by the US Food and Drug Administration.

CPT Code Information

86255

LOINC Code Information

Test ID Test Order Name Order LOINC Value
NF4FS Neurofascin-155 IgG4, S 100845-7

 

Result ID Test Result Name Result LOINC Value
614591 Neurofascin-155 IgG4, S 100845-7