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HelpTest Code NARC Narcolepsy-Associated Antigen, HLA-DQB1 Typing, Blood
Reporting Name
Narcolepsy Associated Ag, BUseful For
Ruling out a diagnosis of narcolepsy
Performing Laboratory
Mayo Clinic Laboratories in Rochester
Specimen Type
Whole Blood ACD-BSpecimen Required
Container/Tube:
Preferred: Yellow top (ACD solution B)
Acceptable: Yellow top (ACD solution A), lavender top (EDTA)
Specimen Volume: 6 mL
Collection Instructions: Send whole blood specimen in original vial. Do not aliquot.
Additional Information: Specimen acceptability is based on extracted DNA concentration and not sample age.
Specimen Minimum Volume
3 mL
Specimen Stability Information
| Specimen Type | Temperature | Time | Special Container |
|---|---|---|---|
| Whole Blood ACD-B | Refrigerated (preferred) | ||
| Ambient | |||
Reference Values
An interpretive report will be provided.
Day(s) Performed
Monday through Friday
Test Classification
This test has been modified from the manufacturer's instructions. Its performance characteristics were determined by Mayo Clinic in a manner consistent with CLIA requirements. This test has not been cleared or approved by the US Food and Drug Administration.CPT Code Information
81376-HLA Class II typing, low resolution (eg, antigen equivalents); one locus (eg, HLA-DRB1/3/4/5, -DQB1, -DQA1, -DPB1, or -DPA1), each
LOINC Code Information
| Test ID | Test Order Name | Order LOINC Value |
|---|---|---|
| NARC | Narcolepsy Associated Ag, B | 63558-1 |
| Result ID | Test Result Name | Result LOINC Value |
|---|---|---|
| NARC_ | Narcolepsy Associated Ag Result | 63558-1 |
| NARCC | Interpretation | 50595-8 |
Interpretation
If DQB1*06:02 is not detected, the narcolepsy-associated antigen test result will be reported as negative for DQB1*06:02.
If the allele is detected, the result will be reported as positive for DQB1*06:02.
Clinical Reference
1. Hurley CK, Kempenich J, Wadsworth K, et al. Common, intermediate and well-documented HLA alleles in world populations: CIWD version 3.0.0. HLA. 2020;95(6):516-531. doi:10.1111/tan.13811
2. Mignot E, Lin X, Arrigoni J, et al. DQB1*0602 and DQB1*0102 (DQ1) are better markers than DR2 for narcolepsy in Caucasian and Black Americans. Sleep 1994;17:S60-67
3. Chabas D, Taheri S, Renier C, Mignot E. The genetics of narcolepsy. Ann Rev Genomics Hum Genet 2003;4:459-483
4. Andlauer O, Moore H 4th, Hong SC, et al. Predictors of hypocretin (orexin) deficiency in narcolepsy without cataplexy Sleep 2012;35(9):1247-1255F
5. Bassetti CLA, Adamantidis A, Burdakov D, et al. Narcolepsy - clinical spectrum, aetiopathophysiology, diagnosis and treatment. Nat Rev Neurol. 2019;15(9):519-539. doi:10.1038/s41582-019-0226-9
6. Capittini C, De Silvestri A, Terzaghi M, et al. Correlation between HLA-DQB1*06:02 and narcolepsy with and without cataplexy: approving a safe and sensitive genetic test in four major ethnic groups. A systematic meta-analysis. Sleep Med. 2018;52:150-157
7. Miyagawa T, Tokunaga K: Genetics of narcolepsy. Hum Genome Var. 2019;6:4. doi:10.1038/s41439-018-0033-7
Report Available
3 to 8 daysMethod Name
Polymerase Chain Reaction (PCR)/Sequence-Specific Oligonucleotide Probes (SSO)