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Test Code MYGLU Myoglobin, Random, Urine

Important Note

This test must be collected at the Main Campus because: 

 

 If specimen is at ambient temperature, the urine must be aliquotted into a urine myoglobin transport tube (Supply T691) within 1 hour of collection.

 

If specimen is refrigerated, the urine must be aliquotted  into a urine myoglobin transport tube (Supply T691) within 2 hours of collection.

Reporting Name

Myoglobin, Random, U

Useful For

Confirming the presence of a myopathy

Performing Laboratory

Mayo Clinic Laboratories in Rochester

Specimen Type

Urine


Specimen Required


Supplies: Urine Myoglobin Transport Tube (T691)

Container/Tube: Plastic, 5-mL urine myoglobin transport tube

Specimen Volume: 4 mL

Collection Instructions:

1. Collect a preservative-free, random urine specimen.

2. If specimen is at ambient temperature, aliquot the urine to a urine myoglobin transport tube within 1 hour of collection. Refrigerate specimen.

3. If specimen is at refrigerate temperature, aliquot the urine to a urine myoglobin transport tube within 2 hours of collection.

Additional Information: Urinary myoglobin is highly unstable unless alkalinized with sodium carbonate preservative.


Specimen Minimum Volume

1 mL

Specimen Stability Information

Specimen Type Temperature Time Special Container
Urine Refrigerated 7 days MYOGLOBIN TRANSPORT TUBE

Reference Values

0-24 mcg/L

Reference values have not been established for patients younger than 18 years; however myoglobin is not expected to be detectable in urine.

Day(s) Performed

Monday through Sunday

Test Classification

This test has been modified from the manufacturer's instructions. Its performance characteristics were determined by Mayo Clinic in a manner consistent with CLIA requirements. This test has not been cleared or approved by the US Food and Drug Administration.

CPT Code Information

83874

LOINC Code Information

Test ID Test Order Name Order LOINC Value
MYGLU Myoglobin, Random, U 2641-9

 

Result ID Test Result Name Result LOINC Value
MYGLU Myoglobin, Random, U 2641-9

Interpretation

Increased excretion of urinary myoglobin is suggestive of one of the disorders or conditions listed in Clinical Information.

 

Most clinically significant elevations are elevated 2 to 10 times normal.

Clinical Reference

1. Chavez LO. Leon M, Einav S, Varon J. Beyond muscle destruction: a systematic review of rhabdomyolysis for clinical practice. Crit Care. 2016;20(1):135

2. Rodriguez-Capote K, Balion CM, Hill SA, Cleve R, Yang L, El Sharif A. Utility of urine myoglobin for the prediction of acute renal failure in patients with suspected rhabdomyolysis: a systematic review. Clin Chem. 2009;55(12):2190-2197

3. Dawley C. Myalgias and myopathies: rhabdomyolysis. FP Essent. 2016;440:28-36

4. Nance JR, Mammen AL. Diagnostic evaluation of rhabdomyolysis. Muscle Nerve. 2015;51(6):793-810. doi:10.1002/mus.24606

5. Yao Z, Yuan P, Hong S, Li M, Jiang L. Clinical features of acute rhabdomyolysis in 55 pediatric patients. Front. Pediatr. 2020;8:539. doi:10.3389/fped.2020.00539

6. Lamb EJ, Jones GRD. Kidney function tests. In: Rifai N, Chiu RWK, Young I, Burnham CAD, Wittwer CT, eds. Tietz Textbook of Laboratory Medicine. 7th ed. Elsevier; 2023:chap 34

Report Available

1 to 2 days

Method Name

Electrochemiluminescent Immunoassay (ECLIA)