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Test Code MYCO Mycoplasma pneumoniae Antibodies, IgG and IgM, Serum

Important Note

5/9/18 This test can now be ordered directly in Cerner. No more need to order as a .Mayo Miscellaneous.

 


Ordering Guidance


Detection of IgM or IgG class antibodies to Mycoplasma pneumoniae provides exposure information. The preferred method of diagnosis of acute M pneumoniae infection is by molecular detection; order MPRP / Mycoplasma pneumoniae, Molecular Detection, PCR, Varies.



Specimen Required


Collection Container/Tube:

Preferred: Serum gel

Acceptable: Red top

Submission Container/Tube: Plastic vial

Specimen Volume: 1 mL

Collection Instructions: Centrifuge and aliquot serum into a plastic vial.


Useful For

Screening for recent or past exposure to Mycoplasma pneumoniae

 

This test should not be used as a screening procedure for the general population.

Profile Information

Test ID Reporting Name Available Separately Always Performed
MYCOG M. pneumoniae Ab, IgG, S No Yes
MYCOM M. pneumoniae Ab, IgM, S No Yes
MYCON M. pneumoniae Ab Interpretation No Yes

Reflex Tests

Test ID Reporting Name Available Separately Always Performed
MMYCO M. pneumoniae Ab, IgM, S by IFA No No

Testing Algorithm

If the Mycoplasma pneumoniae IgM result is reactive or equivocal, then M pneumoniae IgM by indirect immunofluorescence assay will be performed at an additional charge.

Method Name

MYCOG, MYCOM: Enzyme Immunoassay (EIA)

MMYCO: Indirect Immunofluorescence Assay (IFA)

MYCON: Interpretation

Reporting Name

M. pneumoniae Ab, IgG and IgM, S

Specimen Type

Serum

Specimen Minimum Volume

0.5 mL

Specimen Stability Information

Specimen Type Temperature Time Special Container
Serum Refrigerated (preferred) 14 days
  Frozen  14 days

Reference Values

IgG: Negative

IgM: Negative

IgM by indirect immunofluorescence: Negative

Interpretation

IgG ELISA result

IgM ELISA result

Interpretation

Positive

Negative

Results suggest past exposure.

Positive

 

Reactive

Prior exposure to Mycoplasma pneumoniae detected. Confirmatory testing for IgM to M pneumonia will be performed by an immunofluorescence assay.

Equivocal

Negative

Negative

No antibodies to M pneumoniae detected. Acute infection cannot be ruled out as antibody levels may be below the limit of detection.  If clinically indicated, a second serum should be submitted in 14 to 21 days.

Negative

Reactive

No prior exposure to Mycoplasma pneumoniae. Confirmatory testing for IgM to M pneumonia will be performed by an immunofluorescence assay..

Equivocal

Equivocal

Negative

Recommend follow-up testing in 10 to 14 days if clinically indicated.

Reactive

Confirmatory testing for IgM to M pneumonia will be performed by an immunofluorescence assay.

Equivocal

 

ELISA = Enzyme-linked immunosorbent assay

Clinical Reference

1. Smith T: Mycoplasma pneumoniae infections: diagnosis based on immunofluorescence titer of IgG and IgM antibodies. Mayo Clin Proc. 1986 Oct;61(10):830-831

2. Holzman RS, Simberkoff MS, Leaf HL: Mycoplasma pneumoniae and atypical pneumonia. In Bennett JE, Dolin R, Blaser MJ, eds. Mandell, Douglas, and Bennett's Principles and Practice of Infectious Diseases. 9th ed. Elsevier; 2020:2332-2339

Day(s) Performed

Monday through Friday

Report Available

Same day/1 to 3 days

Performing Laboratory

Mayo Clinic Laboratories in Rochester

Test Classification

This test has been modified from the manufacturer's instructions. Its performance characteristics were determined by Mayo Clinic in a manner consistent with CLIA requirements. This test has not been cleared or approved by the US Food and Drug Administration.

CPT Code Information

86738 x 2-Mycoplasma pneumoniae by EIA

86738-Mycoplasma pneumoniae by indirect IFA (if appropriate)

LOINC Code Information

Test ID Test Order Name Order LOINC Value
MYCO M. pneumoniae Ab, IgG and IgM, S 58733-7

 

Result ID Test Result Name Result LOINC Value
MYCOG M. pneumoniae Ab, IgG, S 45224-3
MYCOM M. pneumoniae Ab, IgM, S 5257-1
MYCON M. pneumoniae Ab Interpretation 69048-7

Forms

If not ordering electronically, complete, print, and send Infectious Disease Serology Test Request (T916) with the specimen.