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Test Code MURA Lysozyme (Muramidase), Plasma


Specimen Required


Collection Container/Tube: Lavender top (EDTA)

Submission Container/Tube: Plastic vial

Specimen Volume: 2 mL

Collection Instructions:

1. Centrifuge and aliquot plasma into a plastic vial within 2 hours of collection.

2. Freeze immediately after transferring.


Useful For

As a screening test for ocular sarcoidosis

 

Confirming marked increases in the granulocyte or monocyte pools as in granulocytic or monocytic leukemias, myeloproliferative disorders, and malignant histiocytosis

 

Following the course of therapy in cases of chronic granulocytic or chronic monocytic leukemias

Method Name

Turbidimetric

Reporting Name

Lysozyme (Muramidase), P

Specimen Type

Plasma EDTA

Specimen Minimum Volume

1 mL

Specimen Stability Information

Specimen Type Temperature Time Special Container
Plasma EDTA Frozen 21 days

Reference Values

≥12 months: 2.6-6.0 mcg/mL

Reference values have not been established for patients who are less than12 months of age.

Interpretation

Levels above 200 mcg/mL may be seen in acute nonlymphocytic leukemia (M2, M4, M5) or chronic granulocytic leukemias.

Clinical Reference

1. Catovsky D, Galton DA, Griffin C. The significance of lysozyme estimations in acute myeloid and chronic monocytic leukaemia. Br J Haematol. 1971;21(5):565-580

2. Herbort CP, Roa NA, Mochizuki M, members of Scientific Committee of First International Workshop on Ocular Sarcoidosis. International criteria for the diagnosis of ocular sarcoidosis: Results of the first International Workshop on Ocular Sarcoidosis (IWOS). Ocul Immunol Inflamm. 2009;17(3):160-169

3. Bergantini L, Bianchi F, Cameli P, et al. Prognostic biomarkers of sarcoidosis: a comparative study of serum chitotriosidase, ACE, lysozyme, and KL-6. Dis Markers. 2019;2019:8565423 doi:10.1155/2019/8565423

Performing Laboratory

Mayo Clinic Laboratories in Rochester

Test Classification

This test was developed and its performance characteristics determined by Mayo Clinic in a manner consistent with CLIA requirements. It has not been cleared or approved by the US Food and Drug Administration.

CPT Code Information

85549

LOINC Code Information

Test ID Test Order Name Order LOINC Value
MURA Lysozyme (Muramidase), P 2589-0

 

Result ID Test Result Name Result LOINC Value
MURA Lysozyme (Muramidase), P 2589-0

Day(s) Performed

Monday through Friday

Report Available

2 to 5 days

Forms

If not ordering electronically, complete, print, and send 1 of the following forms with the specimen:

-Benign Hematology Test Request (T755)

Hematopathology/Cytogenetics Test Request (T726)