Home
HelpTest Code MP1BS Microtubule-Associated Protein 1B (MAP1B) Antibody, Immunoblot, Serum (Non-Orderable)
Specimen Required
Only orderable as a reflex. For more information see:
-AIAES / Axonal Neuropathy, Autoimmune/Paraneoplastic Evaluation, Serum
-DMS2 / Dementia, Autoimmune/Paraneoplastic Evaluation, Serum
-DYS2 / Dysautonomia, Autoimmune/Paraneoplastic Evaluation, Serum
-ENS2 / Encephalopathy, Autoimmune/Paraneoplastic Evaluation, Serum
-EPS2 / Epilepsy, Autoimmune/Paraneoplastic Evaluation, Serum
-GID2 / Gastrointestinal Dysmotility, Autoimmune/Paraneoplastic Evaluation, Serum
-MAS1 / Myelopathy, Autoimmune/Paraneoplastic Evaluation, Serum
-MDS2 / Movement Disorder, Autoimmune/Paraneoplastic Evaluation, Serum
Useful For
Only orderable as a reflex. For more information see:
AIAES / Axonal Neuropathy, Autoimmune/Paraneoplastic Evaluation, Serum
DMS2 / Dementia, Autoimmune/Paraneoplastic Evaluation, Serum
DYS2 / Dysautonomia, Autoimmune/Paraneoplastic Evaluation, Serum
ENS2 / Encephalopathy, Autoimmune/Paraneoplastic Evaluation, Serum
EPS2 / Epilepsy, Autoimmune/Paraneoplastic Evaluation, Serum
GID2 / Gastrointestinal Dysmotility, Autoimmune/Paraneoplastic Evaluation, Serum
MAS1 / Myelopathy, Autoimmune/Paraneoplastic Evaluation, Serum
MDS2 / Movement Disorder, Autoimmune/Paraneoplastic Evaluation, Serum
Detecting paraneoplastic neurological autoimmunity using serum specimens
Identifying an underlying cancer
Better characterization of a patient’s neurologic presentation
Evaluating patients with paraneoplastic or autoimmune central nervous system inflammation (brainstem encephalitis or limbic encephalitis or cerebellar ataxia or myelitis) or peripheral nervous system inflammation (including polyradiculopathy or neuropathy) and using serum or cerebrospinal fluid specimens
Method Name
Only orderable as a reflex. For more information see:
-AIAES / Axonal Neuropathy, Autoimmune/Paraneoplastic Evaluation, Serum
-DMS2 / Dementia, Autoimmune/Paraneoplastic Evaluation, Serum
-DYS2 / Dysautonomia, Autoimmune/Paraneoplastic Evaluation, Serum
-ENS2 / Encephalopathy, Autoimmune/Paraneoplastic Evaluation, Serum
-EPS2 / Epilepsy, Autoimmune/Paraneoplastic Evaluation, Serum
-GID2 / Gastrointestinal Dysmotility, Autoimmune/Paraneoplastic Evaluation, Serum
-MAS1 / Myelopathy, Autoimmune/Paraneoplastic Evaluation, Serum
-MDS2 / Movement Disorder, Autoimmune/Paraneoplastic Evaluation, Serum
Immunoblot (IB)
Reporting Name
MAP1B Immunoblot, SSpecimen Type
SerumSpecimen Minimum Volume
Serum:1 mL
Specimen Stability Information
| Specimen Type | Temperature | Time |
|---|---|---|
| Serum | Refrigerated (preferred) | 28 days |
| Frozen | 28 days | |
| Ambient | 72 hours |
Reference Values
Only orderable as a reflex. For more information see:
-AIAES / Axonal Neuropathy, Autoimmune/Paraneoplastic Evaluation, Serum
-DMS2 / Dementia, Autoimmune/Paraneoplastic Evaluation, Serum
-DYS2 / Dysautonomia, Autoimmune/Paraneoplastic Evaluation, Serum
-ENS2 / Encephalopathy, Autoimmune/Paraneoplastic Evaluation, Serum
-EPS2 / Epilepsy, Autoimmune/Paraneoplastic Evaluation, Serum
-GID2 / Gastrointestinal Dysmotility, Autoimmune/Paraneoplastic Evaluation, Serum
-MAS1 / Myelopathy, Autoimmune/Paraneoplastic Evaluation, Serum
-MDS2 / Movement Disorder, Autoimmune/Paraneoplastic Evaluation, Serum
Negative
Interpretation
When positive, this test is strongly linked to small-cell lung carcinoma, occurring in approximately 80% to 90% of microtubule-associated protein 1B (MAP1B)-positive patients who have a malignancy. It also aids diagnosis across a broad clinical spectrum, including peripheral neuropathies such as painless subacute or chronic polyradiculoneuropathy and sensory neuronopathy, as well as central nervous system syndromes like cerebellar ataxia, encephalopathy, myelopathy, and brainstem or cognitive dysfunction. Autonomic features and autoimmune gastrointestinal dysmotility may also occur. Together, these findings help healthcare professionals identify when an otherwise unexplained neurological syndrome may have a paraneoplastic cause.
Clinical Reference
1. Vernino S, Lennon VA. New Purkinje cell antibody (PCA-2): marker of lung cancer-related neurological autoimmunity. Ann Neurol. 2000;47(3):297-305
2. Gadoth A, Kryzer TJ, Fryer J, McKeon A, Lennon VA, Pittock SJ. Microtubule-associated protein 1B: Novel paraneoplastic biomarker. Ann Neurol. 2017;81(2):266-277. doi:10.1002/ana.24872
3. Jitprapaikulsan J, Klein CJ, Pittock SJ, et al. Phenotypic presentations of paraneoplastic neuropathies associated with MAP1B-IgG. J Neurol Neurosurg Psychiatry. 2020;91(3):328-330. doi:10.1136/jnnp-2019-322175
Day(s) Performed
Varies
Report Available
4 daysPerforming Laboratory
Mayo Clinic Laboratories in Rochester
Test Classification
This test was developed and its performance characteristics determined by Mayo Clinic in a manner consistent with CLIA requirements. It has not been cleared or approved by the US Food and Drug Administration.CPT Code Information
84182
LOINC Code Information
| Test ID | Test Order Name | Order LOINC Value |
|---|---|---|
| MP1BS | MAP1B Immunoblot, S | In Process |
| Result ID | Test Result Name | Result LOINC Value |
|---|---|---|
| 621406 | MAP1B Immunoblot, S | In Process |