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Test Code MOWB Molybdenum, Blood

Useful For

Determining molybdenum toxicity

Method Name

Inductively Coupled Plasma Mass Spectrometry (ICP-MS)

Reporting Name

Molybdenum, B

Specimen Type

Whole blood


Specimen Required


Patient Preparation: High concentrations of gadolinium and iodine are known to potentially interfere with most inductively coupled plasma mass spectrometry-based metal tests. If either gadolinium- or iodine-containing contrast media has been administered, a specimen should not be collected for 96 hours.

Supplies: Metal Free B-D Tube (EDTA), 6 mL (T183)

Collection Container/Tube: Royal blue top (EDTA) plastic trace element blood collection tube

Specimen Volume: 0.8 mL

Collection Instructions:

1. See Metals Analysis Specimen Collection and Transport for complete instructions.

2. Send whole blood specimen in original tube. Do not aliquot.


Specimen Minimum Volume

0.25 mL

Specimen Stability Information

Specimen Type Temperature Time Special Container
Whole blood Refrigerated (preferred) 28 days
  Ambient  28 days
  Frozen  28 days

Reference Values

<4 ng/mL (unexposed)

<5 ng/mL (exposed)

Interpretation

Normal blood concentrations are 0.6-4.0 ng/mL in unexposed individuals and 1.2-4.8 ng/mL in exposed individuals.(4)

Clinical Reference

1. Baselt R. Disposition of Toxic Drugs and Chemicals In: Man. 10th ed. Biomedical Publications; 2014

2. Heitland P, Koster HD. Biomonitoring of 37 trace elements in blood samples from inhabitants of northern Germany by ICP-MS. J Trace Elem Med Biol. 2006;20(4):253-262

3. Burguera JL, Burguera M. Molybdenum in human whole blood of adult residents of the Merida State (Venezuela). J Trace Elem Med Biol. 2007;21(3):178-183

4. Werner E, Roth P, Heinrichs U, et al. Internal biokinetic behaviour of molybdenum in humans studied with stable isotopes as tracers. Isotopes Environ Health Stud. 2000;36(2):123-132

5. Abumrad NN, Schneider AJ, Steel D, Rogers LS. Amino acid intolerance during prolonged total parenteral nutrition reversed by molybdate therapy. Am J Clin Nutr. 1981;34(11):2551-2559

6. Momcilovic B. A case report of acute human molybdenum toxicity from a dietary molybdenum supplement--a new member of the "Lucor metallicum" family. Arh Hig Rada Toksikol. 1999;50(3):289-297

7. Gebel T, Claussen K, Dunkelberg H. Human biomonitoring of antimony. Int Arch Occup Environ Health. 1998;71(3):221-224

8. Sodi R. Vitamins and trace elements. In: Rifai N, Chiu RWK, Young I, Burnham CAD, Wittwer CT, eds. Tietz Textbook of Laboratory Medicine. 7th ed. Elsevier; 2023:417-417

9. Witzleb WC, Ziegler J, Krummenauer F, Neumeister V, Guenther KP. Exposure to chromium, cobalt and molybdenum from metal-on-metal total hip replacement and hip resurfacing arthroplasty. Acta Orthop. 2006;77(5):697-705

Day(s) Performed

Wednesday

Report Available

1 to 8 days

Performing Laboratory

Mayo Clinic Laboratories in Rochester

Test Classification

This test was developed and its performance characteristics determined by Mayo Clinic in a manner consistent with CLIA requirements. It has not been cleared or approved by the US Food and Drug Administration.

CPT Code Information

83018

LOINC Code Information

Test ID Test Order Name Order LOINC Value
MOWB Molybdenum, B 5696-0

 

Result ID Test Result Name Result LOINC Value
64272 Molybdenum, B 5696-0