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Test Code MNCU Manganese/Creatinine Ratio, Urine


Specimen Required


Only orderable as part of a profile. For more information see MNRCU / Manganese/Creatinine Ratio, Random, Urine.

Patient Preparation: High concentrations of gadolinium and iodine are known to interfere with most metal tests. If either gadolinium- or iodine-containing contrast media has been administered, a specimen should not be collected for 96 hours.

Supplies: Urine Tubes, 10 mL (T068)

Collection Container/Tube: Clean, plastic urine collection container with no metal cap or glued insert

Submission Container/Tube: Plastic, 10 mL urine tube or clean, plastic aliquot container with no metal cap or glued insert

Specimen Volume: 3 mL

Collection Instructions:

1. Collect a random urine specimen.

2. See Metals Analysis Specimen Collection and Transport for complete instructions.


Useful For

Measurement of manganese as a part of a profile

 

Monitoring manganese exposure

 

Nutritional monitoring

 

Clinical trials

Method Name

Only orderable as part of a profile. For more information see MNRCU / Manganese/Creatinine Ratio, Random, Urine.

 

Triple-Quadrupole Inductively Coupled Plasma-Mass Spectrometry (ICP-MS/MS)

Reporting Name

Manganese/Creat Ratio, U

Specimen Type

Urine

Specimen Stability Information

Specimen Type Temperature Time Special Container
Urine Refrigerated (preferred) 28 days
  Frozen  28 days
  Ambient  7 days

Reference Values

Only orderable as part of a profile. For further information see MNRCU / Manganese/Creatinine Ratio, Random, Urine.

 

0-17 years: Not established

≥18 years: <4.0 mcg/g creatinine

Interpretation

Manganese in urine represents the excretion of excess manganese from the body and may be used to monitor exposure or excessive nutritional intake.

Clinical Reference

1. Levy BS, Nassetta WJ: Neurologic effects of manganese in humans: A review. Int J Occup Environ Health. 2003 Apr-Jun;9(2):153-163. doi: 10.1179/oeh.2003.9.2.153

2. Paschal DC, Ting BG, Morrow JC, et al: Trace metals in urine of United States residents: reference range concentrations. Environ Res. 1998 Jan;76(1):53-59. doi: 10.1006/enrs.1997.3793

3. Rifai N, Chiu RWK, Young I, Burnham CAD, Wittwer CT, eds: Tietz Textbook of Laboratory Medicine. 7th ed. Elsevier; 2023

4. O'Neal SL, Zheng W: Manganese toxicity upon overexposure: a decade in review. Curr Environ Health Rep. 2015 Sep;2(3):315-328. doi: 10.1007/s40572-015-0056-x

Day(s) Performed

Tuesday

Report Available

2 to 8 days

Performing Laboratory

Mayo Clinic Laboratories in Rochester

Test Classification

This test was developed and its performance characteristics determined by Mayo Clinic in a manner consistent with CLIA requirements. It has not been cleared or approved by the US Food and Drug Administration.

CPT Code Information

83785

LOINC Code Information

Test ID Test Order Name Order LOINC Value
MNCU Manganese/Creat Ratio, U 27367-2

 

Result ID Test Result Name Result LOINC Value
614994 Manganese/Creat Ratio, U 27367-2