Home
HelpTest Code MMRV Measles, Mumps, Rubella, and Varicella (MMRV) Immune Status Profile, Serum
Reporting Name
MMRV Immune Status Profile, SUseful For
Determining immune status of individuals to measles, mumps, rubella, and varicella-zoster viruses (VZV)
Documentation of previous infection with measles, mumps, rubella, or VZV in an individual without a previous record of immunization to these viruses
Profile Information
| Test ID | Reporting Name | Available Separately | Always Performed |
|---|---|---|---|
| ROPG | Measles (Rubeola) Ab, IgG, S | Yes | Yes |
| MPPG | Mumps Ab, IgG, S | Yes | Yes |
| RBPG | Rubella Ab, IgG, S | Yes | Yes |
| VZPG | Varicella-Zoster Ab, IgG, S | Yes | Yes |
Performing Laboratory
Mayo Clinic Laboratories in Rochester
Specimen Type
SerumSpecimen Required
Collection Container/Tube:
Preferred: Serum gel
Acceptable: Red top
Submission Instructions: Plastic vial
Specimen Volume: 1 mL
Collection Instructions: Centrifuge and aliquot serum into a plastic vial.
Specimen Minimum Volume
0.4 mL
Specimen Stability Information
| Specimen Type | Temperature | Time | Special Container |
|---|---|---|---|
| Serum | Refrigerated (preferred) | 14 days | |
| Frozen | 14 days |
Reference Values
MEASLES, MUMPS and VARICELLA:
Vaccinated: Positive (≥1.1 AI)
Unvaccinated: Negative (≤0.8 AI)
Reference values apply to all ages
RUBELLA:
Vaccinated: Positive (≥1.0 AI)
Unvaccinated: Negative (≤0.7 AI)
Reference values apply to all ages
CPT Code Information
86735
86762
86765
86787
LOINC Code Information
| Test ID | Test Order Name | Order LOINC Value |
|---|---|---|
| MMRV | MMRV Immune Status Profile, S | 104688-7 |
| Result ID | Test Result Name | Result LOINC Value |
|---|---|---|
| VZG | Varicella-Zoster Ab, IgG, S | 15410-4 |
| RBG | Rubella Ab, IgG, S | 40667-8 |
| MUMG | Mumps Ab, IgG, S | 6476-6 |
| ROG | Measles (Rubeola) Ab, IgG, S | 35275-7 |
| DEXG3 | Measles IgG Antibody Index | 5244-9 |
| DEXG2 | Rubella IgG Antibody Index | 5334-8 |
| DEXG5 | Mumps IgG Antibody Index | 25418-5 |
| DEXG4 | Varicella IgG Antibody Index | 5403-1 |
Interpretation
The reported AI value is for reference only. This is a qualitative test, and the numeric value of the AI is not indicative of the amount of antibody present. AI values above the manufacturer recommended cutoff for this assay indicate that specific antibodies were detected, suggesting prior exposure or vaccination.
Positive measles, mumps, varicella-zoster viruses (VZV): Antibody Index (AI) value ≥1.1
Positive rubella: AI Value ≥1.0
-The presence of detectable IgG-class antibodies to these viruses indicates prior exposure through infection or immunization. Individuals testing positive for IgG-class antibodies to measles, mumps, rubella, or VZV are considered immune.
Equivocal measles, mumps, VZV: AI value 0.9-1.0
Equivocal rubella: AI value 0.8-0.9
-Submit an additional sample for testing in 10 to 14 days to demonstrate IgG seroconversion if recently vaccinated or if otherwise clinically indicated.
Negative measles, mumps, VZV: AI value ≤0.8
Negative rubella: AI value ≤0.7
-The absence of detectable IgG-class antibodies to measles, mumps, rubella, or VZV suggests no prior exposure to these viruses or the lack of a specific immune response to immunization.
Clinical Reference
1. Perry RT, Halsey NA: The clinical significance of measles-a review. J Infect Diseases. 2004;189(Supp 1):S4-S16. doi: 10.1086/377712
2. Centers for Disease Control and Prevention (CDC): Increased transmission and outbreaks of measles-European Region, 2011. MMWR Morb Mortal Wkly Rep. 2011;60(47):1605-1610
3. Hviid A, Rubin S, Muhlemann K: Mumps. Lancet. 2008 Mar;371(9616):932-944
4. Hodinka RL, Moshal KL: Childhood infections. In: Storch GA, ed. Essentials of Diagnostic Virology. Churchill Livingstone; 2000; 168-178
5. American Academy of Pediatrics. Rubella. In: Pickering LK, ed. Red Book. Report of the Committee on Infectious Diseases. 2012
6. Best JM: Rubella. Semin Fetal Neonatal Med. 2007;12(3):182. doi: 10.1016/j.siny.2007.01.017
7. Duszak RS: Congenital rubella syndrome-major review. Optometry. 2009;80(1):36. doi: 10.1016/j.optm.2008.03.006
8. Notifiable diseases and mortality tables. MMWR Morb Mortal Wkly Rep. 2012;61(34):466-479
9. National Center for Immunization and Respiratory Diseases (NCIRD), Division of Viral Diseases: Rubella (German measles, three-day measles). CDC; Updated December 31, 2020. Accessed December 27, 2022. Available at www.cdc.gov/rubella/
10. Yankowitz J, Grose C: Congenital infections. In: Storch GA, ed. Essentials of Diagnostic Virology. Churchill Livingstone; 2000; 187-201
11. Theel ES, Sorenson M, Rahman C, Granger D, Vaughn A, Breeher L: Performance characteristics of a multiplex flow immunoassay for detection of IgG-Class antibodies to measles, mumps, rubella, and Varicella-Zoster viruses in presumptively immune health care workers. J Clin Microbiol. 2020 Mar 25;58(4):e00136-20. doi: 10.1128/JCM.00136-20
Report Available
Same day/1 dayMethod Name
Multiplex Flow Immunoassay (MFI)
Forms
If not ordering electronically, complete, print, and send Infectious Disease Serology Test Request (T916) with the specimen.
Test Classification
This test has been cleared, approved, or is exempt by the US Food and Drug Administration and is used per manufacturer's instructions. Performance characteristics were verified by Mayo Clinic in a manner consistent with CLIA requirements.Day(s) Performed
Monday through Saturday