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Test Code MMPGM Mumps Virus Antibody, IgM and IgG, Serum

Reporting Name

Mumps Ab, IgM and IgG, S

Useful For

Diagnosis of mumps virus infection

 

Determination of postimmunization immune response of individuals to the mumps vaccine

 

Documentation of previous infection with mumps virus in an individual with no previous record of immunization to mumps virus

Profile Information

Test ID Reporting Name Available Separately Always Performed
MMPM Mumps Ab, IgM, S Yes Yes
MPPG Mumps Ab, IgG, S Yes Yes

Performing Laboratory

Mayo Clinic Laboratories in Rochester

Specimen Type

Serum


Specimen Required


Collection Container/Tube:

Preferred: Serum gel

Acceptable: Red top

Submission Container/Tube: Plastic vial

Specimen Volume: 1 mL

Collection Instructions: Centrifuge and aliquot serum into plastic vial.


Specimen Minimum Volume

0.9 mL

Specimen Stability Information

Specimen Type Temperature Time Special Container
Serum Refrigerated (preferred) 14 days
  Frozen  14 days

Reference Values

IgM:

Negative: Index value 0.00-0.79

Reference value applies to all ages.

 

IgG:

Vaccinated: Positive (≥1.1 AI)

Unvaccinated: Negative (≤0.8 AI)

Reference values apply to all ages.

Day(s) Performed

MMPM: Tuesday

MPPG: Monday through Saturday

CPT Code Information

86735-Mumps, IgG

86735-Mumps, IgM

LOINC Code Information

Test ID Test Order Name Order LOINC Value
MMPGM Mumps Ab, IgM and IgG, S 77250-9

 

Result ID Test Result Name Result LOINC Value
MUMP1 Mumps Ab, IgM, S 6478-2
MUMG Mumps Ab, IgG, S 6476-6
DEXM Index Value 25419-3
DEXG5 Mumps IgG Antibody Index 25418-5

Interpretation

A positive IgG result coupled with a positive IgM result suggests recent infection with mumps virus. This result should not be used alone to diagnose mumps infection and should be interpreted in the context of clinical presentation.

 

A positive IgG result coupled with a negative IgM result indicates previous vaccination to or infection with mumps virus. These individuals are considered to have protective immunity to reinfection.

 

A negative IgG result coupled with a negative IgM result indicates the absence of prior exposure to mumps virus and nonimmunity. However, a negative result does not rule-out mumps infection or response to vaccination. The specimen may have been collected before the appearance of detectable antibodies. Negative results in suspected early mumps infection or within a week following vaccination should be followed by testing a new serum specimen in 2 to 3 weeks.

 

Equivocal results should be followed up with testing of a new serum specimen within 10 to 14 days.

Clinical Reference

1. Hviid A, Rubin S, Muhlemann K. Mumps. Lancet. 2008;371(9616):932-944

2. Hodinka RL, Moshal KL.Childhood infections. In: Storch GA, ed. Essentials of Diagnostic Virology. Churchill Livingstone; 2000:168-178

3. Litman N, Baum SG. Mumps virus. In: Bennett JE, Dolin R, Blaser MJ, eds. Mandell, Douglas, and Bennett's Principles and Practice of Infectious Diseases. 9th ed. Elsevier; 2020:2087-2092

Report Available

1 to 7 days

Method Name

MMPM: Enzyme Immunoassay (EIA)

MPPG: Multiplex Flow Immunoassay

Test Classification

This test has been cleared, approved, or is exempt by the US Food and Drug Administration and is used per manufacturer's instructions. Performance characteristics were verified by Mayo Clinic in a manner consistent with CLIA requirements.

Forms

If not ordering electronically, complete, print, and send Infectious Disease Serology Test Request (T916) with the specimen.