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Test Code MITAN Mitotane, Plasma


Shipping Instructions


Ship specimen refrigerated.



Specimen Required


Collection Container/Tube: Green top (sodium heparin) (Lithium heparin and PST/plasma gel tubes are not acceptable.)

Submission Container/Tube: Plastic vial

Specimen Volume: 1 mL

Collection Instructions: Within 2 hours of collection, centrifuge and aliquot plasma into plastic vial.


Useful For

Assessing compliance or making dosage adjustments for mitotane

Method Name

Gas Chromatography Mass Spectrometry (GC-MS) Confirmation with Quantitation

Reporting Name

Mitotane, P

Specimen Type

Plasma Na Heparin

Specimen Minimum Volume

0.5 mL

Specimen Stability Information

Specimen Type Temperature Time
Plasma Na Heparin Refrigerated (preferred) 21 days
  Frozen  28 days
  Ambient  72 hours

Reference Values

Therapeutic: 14-20 mcg/mL

Interpretation

In the literature when mitotane is used to treat adrenocortical carcinoma, the maximum benefit is seen when plasma mitotane concentrations are between 14-20 mcg/mL.

Clinical Reference

1. Feliu C, Cazaubon Y, Guillemin H, et al. Therapeutic drug monitoring of mitotane: Analytical assay and patient follow-up. Biomed Chromatogr. 2017;31(11):10.1002/bmc.3993. doi:10.1002/bmc.3993

2. Ando M, Hirabatake M, Yasui H, Fukushima S, Sugioka N, Hashida T. A simplified method for therapeutic drug monitoring of mitotane by gas chromatography-electron ionization-mass spectrometry. Biomed Chromatogr. 2020;34(3):e4776. doi:10.1002/bmc.4776

Day(s) Performed

Tuesday, Thursday

Report Available

2 to 7 days

Performing Laboratory

Mayo Clinic Laboratories in Rochester

Test Classification

This test was developed and its performance characteristics determined by Mayo Clinic in a manner consistent with CLIA requirements. It has not been cleared or approved by the US Food and Drug Administration.

CPT Code Information

80299

LOINC Code Information

Test ID Test Order Name Order LOINC Value
MITAN Mitotane, P 13626-7

 

Result ID Test Result Name Result LOINC Value
621811 Mitotane, P 13626-7