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HelpTest Code MAGES Myelin-Associated Glycoprotein Autoantibodies, IgM, Serum
Specimen Required
Collection Container/Tube:
Preferred: Red top
Acceptable: Serum gel
Submission Container/Tube: Plastic vial
Specimen Volume: 1 mL
Collection Instructions: Centrifuge and aliquot serum into a plastic vial.
Forms
If not ordering electronically, complete, print, and send a Neurology Specialty Testing Client Test Request (T732) with the specimen.
Useful For
Evaluating peripheral neuropathy
Evaluating paraproteinemic neuropathy
Method Name
Enzyme-Linked Immunosorbent Assay (ELISA)Reporting Name
MAG IgM, SSpecimen Type
SerumSpecimen Minimum Volume
0.5 mL
Specimen Stability Information
| Specimen Type | Temperature | Time | Special Container |
|---|---|---|---|
| Serum | Refrigerated (preferred) | 28 days | |
| Frozen | 28 days | ||
| Ambient | 72 hours |
Reference Values
<1500 Buhlmann Titer Unit
Interpretation
A positive result is consistent with anti-myelin-associated glycoprotein neuropathy.
Clinical Reference
1. Kuijf ML, Eurelings M, Tio-Gillen AP, et al: Detection of anti-MAG antibodies in polyneuropathy associated with IgM monoclonal gammopathy. Neurology. 2009 Sep;73(9):688-695. doi: 10.1212/WNL.0b013e3181b59a80
2. Katz JS, Saperstein DS, Gronseth G, Amato AA, Barohn RJ: Distal acquired demyelinating symmetric neuropathy. Neurology. 2000 Feb;54(3):615-620. doi: 10.1212/wnl.54.3.615
3. Magy L, Kabore R, Mathis S, et al: Heterogeneity of polyneuropathy associated with anti-MAG antibodies. J Immunol Res. 2015;2015:450391. doi: 10.1155/2015/450391
Day(s) Performed
Tuesday, FridayReport Available
2 to 6 daysPerforming Laboratory
Mayo Clinic Laboratories in Rochester
Test Classification
This test was developed and its performance characteristics determined by Mayo Clinic in a manner consistent with CLIA requirements. It has not been cleared or approved by the US Food and Drug Administration.CPT Code Information
83520
LOINC Code Information
| Test ID | Test Order Name | Order LOINC Value |
|---|---|---|
| MAGES | MAG IgM, S | 39087-2 |
| Result ID | Test Result Name | Result LOINC Value |
|---|---|---|
| 607034 | MAG IgM, S | 39087-2 |