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HelpTest Code LKM Liver/Kidney Microsome Type 1 Antibodies, Serum
Reporting Name
Liver/Kidney Microsome Type 1 Ab, SUseful For
Evaluation of patients with liver disease of unknown etiology
Evaluation of patients with suspected autoimmune hepatitis
Performing Laboratory
Mayo Clinic Laboratories in Rochester
Specimen Type
SerumSpecimen Required
Supplies: Sarstedt Aliquot Tube, 5 mL (T914)
Collection Container/Tube:
Preferred: Serum gel
Acceptable: Red top
Submission Container/Tube: Plastic vial
Specimen Volume: 0.5 mL
Collection Instructions: Centrifuge and aliquot serum into a plastic vial.
Specimen Minimum Volume
0.4 mL
Specimen Stability Information
| Specimen Type | Temperature | Time | Special Container |
|---|---|---|---|
| Serum | Refrigerated (preferred) | 21 days | |
| Frozen | 21 days |
Reference Values
≤20.0 Units (Negative)
20.1-24.9 Units (Equivocal)
≥25.0 Units (Positive)
Reference values apply to all ages.
Day(s) Performed
Monday, Wednesday, Friday
Test Classification
This test has been cleared, approved, or is exempt by the US Food and Drug Administration and is used per manufacturer's instructions. Performance characteristics were verified by Mayo Clinic in a manner consistent with CLIA requirements.CPT Code Information
86376
LOINC Code Information
| Test ID | Test Order Name | Order LOINC Value |
|---|---|---|
| LKM | Liver/Kidney Microsome Type 1 Ab, S | 32220-6 |
| Result ID | Test Result Name | Result LOINC Value |
|---|---|---|
| LKM | Liver/Kidney Microsome Type 1 Ab, S | 32220-6 |
Interpretation
Seropositivity for anti-liver/kidney microsomal antibodies type 1 antibodies is consistent with a diagnosis of autoimmune hepatitis type 2, in patients with compatible clinical symptoms and histopathology.
Clinical Reference
1. Mieli-Vergani G, Vergani D, Czaja AJ, et al. Autoimmune hepatitis. Primer. 2018;4:18017. doi:10.1038/nrdp.2018.17
2. Beretta-Piccoli BT, Mieli-Vergani G, Vergani D. Serology in autoimmune hepatitis: A clinical-practice approach. Eur J Intern Med. 2018;48:35-43. doi:10.1016/j.ejim.2017.10.006
3. Toh BH. Diagnostic autoantibodies for autoimmune liver diseases. Clin Transl Immunology. 2017;6(5):e139. doi:10.1038/cti.2017.14
4. Liberal R, Mieli-Vergani G, Vergani D. Clinical significance of autoantibodies in autoimmune hepatitis. J Autoimmun. 2013;46:17-24. doi:10.1016/j.jaut.2013.08.001
5. Manns MP, Johnson EF, Griffin KJ, Tan EM, Sullivan KF. Major antigen of liver kidney microsomal autoantibodies in idiopathic autoimmune hepatitis is cytochrome P450db1. J Clin Invest. 1989;83(3):1066-1072. doi:10.1172/JCI1139496
6. Hennes EM, Zeniya M, Czaja AJ, et. Al. Simplified criteria for the diagnosis of autoimmune hepatitis. Hepatology. 2008;48(1):169-76. doi:10.1002/hep.22322
7. Ducazu O, Degroote H, Geerts A, et al. Diagnostic and prognostic scoring systems for autoimmune hepatitis: a review. Acta Gastroenterol Belg. 2021;84(3):487-495. doi:10.51821/84.3.014.
8. Harrington C, Krishnan S, Mack CL, Cravedi P, Assis DN, Levitsky J. Noninvasive biomarkers for the diagnosis and management of autoimmune hepatitis. Hepatology. 2022;76(6):1862-1879. doi:10.1002/hep.32591
Report Available
2 to 4 daysMethod Name
Enzyme-Linked Immunosorbent Assay (ELISA)
Forms
If not ordering electronically, complete, print, and send 1 of the following with the specimen:
-Gastroenterology and Hepatology Test Request (T728)
-General Request (T239)
Testing Algorithm
For more information see First-Line Screening for Autoimmune Liver Disease Algorithm.