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Test Code K11CC Kelch-Like Protein 11 Antibody, Cell Binding Assay, Spinal Fluid


Specimen Required


Container/Tube: Sterile vial

Specimen Volume: 2 mL


Useful For

Evaluating patients with paraneoplastic or autoimmune encephalitis (brainstem encephalitis or limbic encephalitis or cerebellar ataxia) using spinal fluid specimens

Reflex Tests

Test ID Reporting Name Available Separately Always Performed
K11TC KLHL11 Ab IFA Titer, CSF No No

Testing Algorithm

If the cell binding antibody result is reactive, then the immunofluorescence titer assay will be performed at an additional charge.

Method Name

Cell-Binding Assay (CBA)

Reporting Name

KLHL11 Ab CBA, CSF

Specimen Type

CSF

Specimen Minimum Volume

1 mL

Specimen Stability Information

Specimen Type Temperature Time Special Container
CSF Refrigerated (preferred) 28 days
  Frozen  28 days
  Ambient  72 hours

Reference Values

Negative

Interpretation

Positivity for Kelch-like protein 11 (KLHL11)-IgG is indicative of a paraneoplastic neurological syndrome. Positivity indicates a high likelihood of finding a testicular cancer. A rigorous search for cancer should be initiated after KLHL11 autoimmunity is confirmed.

Clinical Reference

1. Mandel-Brehm C, Dubey D, Kryzer TJ, et al: Kelch-like protein 11 antibodies in seminoma-associated paraneoplastic encephalitis. N Engl J Med. 2019;381:47-54

2. Dubey D, Wilson MR, Clarkson B, et al: Expanded clinical phenotype, oncological associations, and immunopathologic insights of paraneoplastic Kelch-like protein-11 encephalitis. JAMA Neurol. 2020 Aug 3;77(11):1-10

Day(s) Performed

Varies

Report Available

3 to 5 days

Performing Laboratory

Mayo Clinic Laboratories in Rochester

Test Classification

This test was developed and its performance characteristics determined by Mayo Clinic in a manner consistent with CLIA requirements. It has not been cleared or approved by the US Food and Drug Administration.

CPT Code Information

0432U

LOINC Code Information

Test ID Test Order Name Order LOINC Value
K11CC KLHL11 Ab CBA, CSF 99073-9

 

Result ID Test Result Name Result LOINC Value
610580 KLHL11 Ab CBA, CSF 99073-9

Forms

If not ordering electronically, complete, print, and send a Neurology Specialty Testing Client Test Request (T732) with the specimen.