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HelpTest Code JIP Joint Infection Panel, PCR, Synovial Fluid
Ordering Guidance
This test is appropriate for raw, unprocessed, and untreated synovial fluid specimens only.
Shipping Instructions
Specimen must arrive at refrigerated temperature within 7 days of collection.
Specimen Required
Specimen Type: Synovial fluid
Container/Tube: Sterile vial
Specimen Volume: 1 mL
Collection Instructions:
1. Do not process or treat sample in any way.
2. Label specimen as synovial fluid.
Useful For
Rapid detection of synovial fluid infections caused by the following:
Anaerococcus prevotii/vaginalis
Finegoldia magna
Streptococcus species
Clostridium perfringens
Parvimonas micra
Streptococcus agalactiae
Cutibacterium avidum/granulosum
Peptoniphilus species
Streptococcus pneumoniae
Enterococcus faecalis
Peptostreptococcus anaerobius
Streptococcus pyogenes
Enterococcus faecium
Staphylococcus aureus
Staphylococcus lugdunensis
Bacteroides fragilis
Kingella kingae
Proteus species
Citrobacter species
Klebsiella aerogenes
Pseudomonas aeruginosa
Enterobacter cloacae complex
Klebsiella pneumoniae complex
Salmonella species
Escherichia coli
Morganella morganii
Serratia marcescens
Haemophilus influenzae
Neisseria gonorrhoeae
Candida species
Candida albicans
This test is not recommended as a test of cure.
Method Name
Multiplex Polymerase Chain Reaction (PCR)
Reporting Name
Joint Infect Panel PCR, Synovial FlSpecimen Type
Synovial FluidSpecimen Minimum Volume
0.5 mL
Specimen Stability Information
| Specimen Type | Temperature | Time | Special Container |
|---|---|---|---|
| Synovial Fluid | Refrigerated (preferred) | 7 days | |
| Ambient | 4 hours |
Reference Values
Undetected
Interpretation
Results are intended to aid in the diagnosis of illness and are meant to be used in conjunction with other clinical and epidemiological findings.
Detected results do not distinguish between a viable or replicating organism and a nonviable organism or nucleic acid, nor do they exclude the potential for coinfection by organisms not included in the panel.
Negative results do not exclude the possibility of infection and should not be used as the sole basis for diagnosis, treatment, or other management decisions.
The antimicrobial resistance genes detected may or may not be associated with the agents responsible for disease. Undetected results for the included antimicrobial resistance genes do not guarantee susceptibility to corresponding classes of antimicrobials, as other mechanisms of antimicrobial resistance exist.
Clinical Reference
1. Tande AJ, Patel R. Prosthetic Join Infection. Clin Micrbiol Rev. 2014;27(2):302-345. doi:10.1128/CMR.00111-13
2. Berendt T, Byren I. Bone and joint infection. Clin Med (Lond). 2004;4(6):510-518. doi:10.7861/clinmedicine.4-6-510
3. Lipsky BA, Weigelt JA, Gupta V, Killian A, Peng MM. Skin, Soft Tissue, Bone, and Joint Infections in Hospitalized Patients: Epidemiology and Microbiological, Clinical, and Economic Outcomes. Infect Control Hosp Epidemiol. 2007;28(11):1290-1298. doi:10.1086/520743
4. Grammatico-Guillon L, Baron S, Gettner S, et al. Bone and joint infections in hospitalized patients in France, 2008: clinical and economic outcomes. J Hosp Infect. 2012;82(1):40-48. doi:10.1016/j.jhin.2012.04.025
5. Faust SN, Clark J, Pallett A, Clarke NMP. Managing bone and joint infection in children. Arch Dis Child. 2012;97(6):545-553. doi:10.1136/archdischild-2011-301089
6. Esteban J, Salar-Vidal L, Schmitt BH. Multicenter evaluation of the BIOFIRE Joint Infection Panel for the detection of bacteria, yeast, and AMR genes in synovial fluid samples. J Clin Microbiol. 2023;61(11):e0035723. doi:10.1128/jcm.00357-23
Day(s) Performed
Monday through Sunday
Report Available
1 to 2 daysPerforming Laboratory
Mayo Clinic Laboratories in Rochester
Test Classification
This test has been cleared, approved, or is exempt by the US Food and Drug Administration and is used per manufacturer's instructions. Performance characteristics were verified by Mayo Clinic in a manner consistent with CLIA requirements.CPT Code Information
87999
LOINC Code Information
| Test ID | Test Order Name | Order LOINC Value |
|---|---|---|
| JIP | Joint Infect Panel PCR, Synovial Fl | 97608-4 |
| Result ID | Test Result Name | Result LOINC Value |
|---|---|---|
| 621730 | CTX-M | 88250-6 |
| 621731 | IMP | 85498-4 |
| 621732 | KPC | 49617-4 |
| 621733 | mecA/C and MREJ (MRSA) | 96309-0 |
| 621734 | NDM | 73982-1 |
| 621735 | OXA-48-like | 85827-4 |
| 621736 | vanA/B | 62261-3 |
| 621737 | VIM | 85501-5 |
| 621700 | Anaerococcus prevotii/vaginalis | 97609-2 |
| 621714 | Bacteroides fragilis | 97610-0 |
| 621729 | Candida albicans | 97611-8 |
| 621728 | Candida spp. | 97612-6 |
| 621715 | Citrobacter spp. | 97613-4 |
| 621701 | Clostridium perfringens | 97614-2 |
| 621702 | Cutibacterium avidum/granulosum | 97615-9 |
| 621716 | Enterobacter cloacae complex | 97616-7 |
| 621703 | Enterococcus faecalis | 97617-5 |
| 621704 | Enterococcus faecium | 97618-3 |
| 621717 | Escherichia coli | 97619-1 |
| 621705 | Finegoldia magna | 97620-9 |
| 621718 | Haemophilus influenzae | 97621-7 |
| 621719 | Kingella kingae | 97622-5 |
| 621720 | Klebsiella aerogenes | 97623-3 |
| 621721 | Klebsiella pneumoniae complex | 97624-1 |
| 621722 | Morganella morganii | 97625-8 |
| 621723 | Neisseria gonorrhoeae | 97626-6 |
| 621706 | Parvimonas micra | 97627-4 |
| 621707 | Peptoniphilus spp. | 97628-2 |
| 621708 | Peptostreptococcus anaerobius | 97629-0 |
| 621724 | Proteus spp. | 97630-8 |
| 621725 | Pseudomonas aeruginosa | 97631-6 |
| 621726 | Salmonella spp. | 97632-4 |
| 621727 | Serratia marcescens | 97633-2 |
| 621709 | Staphylococcus aureus | 97634-0 |
| 621710 | Staphylococcus lugdunensis | 97635-7 |
| 621711 | Streptococcus agalactiae | 97636-5 |
| 621712 | Streptococcus pneumoniae | 97637-3 |
| 621713 | Streptococcus pyogenes | 97638-1 |
| 621827 | Streptococcus spp. | 97639-9 |
| 621738 | Interpretation | 59464-8 |