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Test Code JCPCR JC Virus, Molecular Detection, PCR, Spinal Fluid


Specimen Required


Supplies: Sarstedt Aliquot Tube, 5 mL (T914)

Preferred: 12 x 75-mm screw cap vial

Acceptable: Sterile screw cap vial

Container/Tube: Sterile vial

Specimen Volume: 0.5 mL

Collection Instructions: Do not centrifuge.


Useful For

Aiding in diagnosing progressive multifocal leukoencephalopathy due to JC virus

 

This test is not to be used as a diagnostic tool for Creutzfeldt-Jakob disease

 

This test is not recommended for screening asymptomatic patients

Testing Algorithm

For more information see Meningitis/Encephalitis Panel Algorithm.

Method Name

Real-Time Polymerase Chain Reaction (PCR)/DNA Probe Hybridization

Reporting Name

JC Virus, PCR, CSF

Specimen Type

CSF

Specimen Minimum Volume

0.3 mL

Specimen Stability Information

Specimen Type Temperature Time Special Container
CSF Refrigerated (preferred) 7 days
  Frozen  7 days

Reference Values

Negative

Interpretation

Detection of JC virus (JCV) DNA supports the clinical diagnosis of progressive multifocal leukoencephalopathy due to JCV.

Clinical Reference

1. Safak M, Khalili K. An overview: human polyomavirus JC virus and its associated disorders. J Neurovirol. 2003;9 Suppl 1:3-9

2. Khalili K, White MK. Human demyelinating disease and the polyomavirus JCV. Mult Scler. 2006;12(2):133-142

3. Ahsan N, Shah KV. Polyomaviruses and human diseases. Adv Exp Med Biol. 2006;577:1-18

4. Romero JR, Kimberlin DW. Molecular diagnosis of viral infections of the central nervous system. Clin Lab Med. 2003;23(4):843-865

5. Chen Y, Bord E, Tompkins T, et al. Asymptomatic reactivation of JC virus in patients treated with natalizumab. N Engl J Med. 2009;361(11):1067-1074

6. Egli A, Infanti L, Dumoulin A, et al. Prevalence of polyomavirus BK and JC infection and replication in 400 healthy donors. J Infect Dis. 2009;199(6):837-846

7. Kartau M, Auvinen E, Verkkoniemi-Ahola A, et al. JC polyomavirus DNA detection in clinical practice. J Clin Virol. 2022;146:105051. doi:10.1016/j.jcv.2021.105051

Day(s) Performed

Monday through Friday

Report Available

Same day/ 1 to 4 days

Performing Laboratory

Mayo Clinic Laboratories in Rochester

Test Classification

This test was developed and its performance characteristics determined by Mayo Clinic in a manner consistent with CLIA requirements. It has not been cleared or approved by the US Food and Drug Administration.

CPT Code Information

87798

LOINC Code Information

Test ID Test Order Name Order LOINC Value
JCPCR JC Virus, PCR, CSF 33295-7

 

Result ID Test Result Name Result LOINC Value
618305 JC Virus, PCR, CSF 33295-7

Forms

If not ordering electronically, complete, print, and send a Microbiology Test Request (T244) with the specimen.