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HelpTest Code INHAB Inhibin A and B, Tumor Marker, Serum
Reporting Name
Inhibin A and B, Tumor Marker, SUseful For
Aiding in the diagnosis of granulosa cell tumors and mucinous epithelial ovarian tumors
Monitoring of patients with granulosa cell tumors and epithelial mucinous-type tumors of the ovary known to secrete inhibin A or overexpress inhibin B
Profile Information
| Test ID | Reporting Name | Available Separately | Always Performed |
|---|---|---|---|
| INHA | Inhibin A, Tumor Marker, S | Yes | Yes |
| INHB | Inhibin B, S | Yes | Yes |
Performing Laboratory
Mayo Clinic Laboratories in Rochester
Specimen Type
SerumSpecimen Required
Supplies: Sarstedt Aliquot Tube 5 mL (T914)
Collection Container/Tube:
Preferred: Serum gel
Acceptable: Red top
Submission Container/Tube: Plastic vial
Specimen Volume: 1.1 mL
Collection Instructions: Centrifuge and aliquot serum into a plastic vial.
Specimen Minimum Volume
0.9 mL
Specimen Stability Information
| Specimen Type | Temperature | Time | Special Container |
|---|---|---|---|
| Serum | Refrigerated (preferred) | 14 days | |
| Frozen | 90 days | ||
| Ambient | 7 days |
Reference Values
INHIBIN A, TUMOR MARKER
Males: <5.0 pg/mL
Females
<11 years: <5.0 pg/mL
11-17 years: <98 pg/mL
Premenopausal: <98 pg/mL
Postmenopausal: <5.0 pg/mL
INHIBIN B
Males
<15 days: 68-373 pg/mL
15-180 days: 42-516 pg/mL
6 months-7 years: 24-300 pg/mL
8-30 years: 47-383 pg/mL
31-72 years: <358 pg/mL
>72 years: Not established
Females
≤12 years: <183 pg/mL
13-41 years regular Cycle (Follicular Phase): <224 pg/mL
42-51 years regular Cycle (Follicular Phase): <108 pg/mL
13-51 years regular Cycle (Luteal Phase): <80 pg/mL
>51 years (Postmenopausal): <12 pg/mL
Day(s) Performed
Monday, Wednesday, Friday
CPT Code Information
83520-Inhibin B
86336-Inhibin A
LOINC Code Information
| Test ID | Test Order Name | Order LOINC Value |
|---|---|---|
| INHAB | Inhibin A and B, Tumor Marker, S | 87426-3 |
| Result ID | Test Result Name | Result LOINC Value |
|---|---|---|
| INHA | Inhibin A, Tumor Marker, S | 23883-2 |
| 88722 | Inhibin B, S | 56940-0 |
Interpretation
Inhibin A levels are elevated in approximately 70% of patients with granulosa cell tumors and in approximately 20% of patients with epithelial ovarian tumors.
Inhibin B levels are elevated in approximately 89% to 100% of patients with granulosa cell tumors and in approximately 55% to 60% of patients with epithelial ovarian tumors.
A normal inhibin A or B level does not rule out a mucinous or granulosa ovarian cell tumor.
For monitoring of patients with known ovarian cancer, inhibin A and B levels decrease shortly after surgery. Elevations of inhibin A or B after treatment are suggestive of residual, recurrent, or progressive disease. In patients with recurrent disease, inhibin A or B elevation seems to be present earlier than clinical symptoms. Patients in remission show normal levels of inhibin A and B.
For infertility evaluation, an inhibin B level in the postmenopausal range is suggestive of a diminished or depleted ovarian reserve.
Clinical Reference
1. Mom CH, Engelen MJA, Willemse PHB, et al. Granulosa cell tumors of the ovary: the clinical value of serum inhibin A and B levels in a large single center cohort. Gynecol Oncol. 2007;105(2):365-372
2. Robertson DM, Pruysers E, Jobling T. Inhibin as a diagnostic marker for ovarian cancer. Cancer Lett. 2007;249(1):14-17
3. Jamieson S, Fuller PJ: Management of granulosa cell tumour of the ovary. Curr Opin Oncol. 2008 Sep;20(5):560-564
4. Sturgeon C. Tumor markers. In: Rifai N, Horvath AR, Wittwer CT, eds. Tietz Textbook of Clinical Chemistry and Molecular Diagnostics. 6th ed. Elsevier; 2018:436-478
5. Yarbrough ML, Stout M, Gronowski AM. Pregnancy and its disorders. In: Rifai N, Horvath AR, Wittwer CT, eds. Tietz Textbook of Clinical Chemistry and Molecular Diagnostics. 6th ed. Elsevier; 2018:1655-1696
6. Makanji Y, Zhu J, Mishra R, et al. Inhibin at 90: from discovery to clinical application, a historical review. Endocr Rev. 2014;35(5):747-794. doi: 10.1210/er.2014-1003
7. Walentowicz P, Krintus M, Sadlecki P, et al. Serum inhibin A and inhibin B levels in epithelial ovarian cancer patients. PLoS One. 2014;9(3):e90575. doi: 10.1371/journal.pone.0090575
Report Available
2 to 4 daysMethod Name
INHA: Immunoenzymatic Assay
INHB: Enzyme-Linked Immunosorbent Assay (ELISA)
Forms
If not ordering electronically, complete, print, and send an Oncology Test Request (T729) with the specimen.