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HelpTest Code IGE Immunoglobulin E (IgE), Serum
Reporting Name
Immunoglobulin E (IgE), SUseful For
Evaluating patients with suspected diseases associated with elevations in total IgE, including allergic disease, primary immunodeficiencies, infections, malignancies, or other inflammatory diseases
Diagnostic evaluation of patients with suspected allergic bronchopulmonary aspergillosis
Identifying candidates for omalizumab (anti-IgE) therapy
Performing Laboratory
Mayo Clinic Laboratories in Rochester
Specimen Type
SerumOrdering Guidance
For a listing of allergens available for testing, see Allergens - Immunoglobulin E (IgE) Antibodies
Specimen Required
Supplies: Sarstedt Aliquot Tube, 5 mL (T914)
Collection Container/Tube:
Preferred: Serum gel
Acceptable: Red top
Submission Container/Tube: Plastic vial
Specimen Volume: 0.5 mL
Collection Instructions: Centrifuge and aliquot serum into a plastic vial.
Specimen Minimum Volume
For only total IgE: 0.3 mL
For total IgE and more than 1 allergen: 0.05 mL x number of allergen-specific tests + 0.25 mL dead space
Specimen Stability Information
| Specimen Type | Temperature | Time |
|---|---|---|
| Serum | Refrigerated (preferred) | 14 days |
| Frozen | 90 days |
Reference Values
0-5 months: ≤13 kU/L
6-11 months: ≤34 kU/L
1 and 2 years: ≤97 kU/L
3 years: ≤199 kU/L
4-6 years: ≤307 kU/L
7 and 8 years: ≤403 kU/L
9-12 years: ≤696 kU/L
13-15 years: ≤629 kU/L
16 and 17 years : ≤537 kU/L
18 years or older: ≤214 kU/L
Day(s) Performed
Monday through Friday
Test Classification
This test has been cleared, approved, or is exempt by the US Food and Drug Administration and is used per manufacturer's instructions. Performance characteristics were verified by Mayo Clinic in a manner consistent with CLIA requirements.CPT Code Information
82785
LOINC Code Information
| Test ID | Test Order Name | Order LOINC Value |
|---|---|---|
| IGE | Immunoglobulin E (IgE), S | 19113-0 |
| Result ID | Test Result Name | Result LOINC Value |
|---|---|---|
| IGE | Immunoglobulin E (IgE), S | 19113-0 |
Interpretation
Elevated concentrations of total IgE may be found in a variety of clinical diseases including allergic disease, certain primary immunodeficiencies, infections, inflammatory diseases, and malignancies.
Elevated total IgE concentrations may be consistent with a diagnosis of allergic bronchopulmonary aspergillosis, provided other laboratory and clinical criteria are fulfilled.
Total IgE concentrations between 30 to 700 kU/L may identify candidates for omalizumab therapy and may help to determine proper therapeutic dosing.
Clinical Reference
1. Homburger HA: Allergic diseases. In: Clinical Diagnosis and Management by Laboratory Methods. 21st ed. WB Saunders Company. 2007;961-971
2. Martins TB, Bandhauer ME, Bunker AM, Roberts WL, Hill HR. New childhood and adult reference intervals for total IgE. J Allergy Clin Immunol. 2014;133(2):589-591
3. Bernstein IL, Li JT, Bernstein DI, et al. Allergy diagnostic testing: An updated practice parameter. Ann Allergy Asthma Immunol. 2008;100(3 Suppl 3):S1-148
4. Ansotegui IJ, Melioli G, Canonica GW, et al. IgE allergy diagnostics and other relevant tests in allergy, a World Allergy Organization position paper. World Allergy Organ J. 2020;13(2):100080. doi:10.1016/j.waojou.2019.100080
Report Available
Same day/1 day to 3 daysMethod Name
Fluorescence Enzyme Immunoassay (FEIA)