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Test Code HYOX Hyperoxaluria Panel, Random, Urine

Reporting Name

Hyperoxaluria Panel, U

Useful For

Distinguishing between primary and secondary hyperoxaluria

 

Distinguishing between primary hyperoxaluria types 1, 2, and 3

Performing Laboratory

Mayo Clinic Laboratories in Rochester

Specimen Type

Urine


Necessary Information


1. Patient age is required.

2. Biochemical Genetics Patient Information (T602) is recommended, but not required, to be filled out and sent with the specimen to aid in the interpretation of test results.



Specimen Required


Supplies: Urine Tubes, 10 mL (T068)

Container/Tube: Plastic, 10-mL urine tube

Specimen Volume: 10 mL

Collection Instructions:

1. Collect a random urine specimen.

2. No preservative.

3. Immediately freeze specimen.


Specimen Minimum Volume

1.1 mL

Specimen Stability Information

Specimen Type Temperature Time
Urine Frozen (preferred) 90 days
  Refrigerated  14 days

Special Instructions

Reference Values

Glycolate

≤17 years: ≤75 mg/g creatinine

≥18 years: ≤50 mg/g creatinine

 

Glycerate

≤31 days: ≤75 mg/g creatinine

32 days - 4 years: ≤125 mg/g creatinine

5 - 10 years: ≤55 mg/g creatinine

≥11 years: ≤25 mg/g creatinine

 

Oxalate

≤6 months: ≤400 mg/g creatinine

7 months - 1 year: ≤300 mg/g creatinine

2 - 6 years: ≤150 mg/g creatinine

7 - 10 years: ≤100 mg/g creatinine

≥11 years: ≤75 mg/g creatinine

 

4-hydroxy-2-oxoglutarate (HOG)

≤10 mg/g creatinine

Day(s) Performed

Wednesday

Test Classification

This test was developed and its performance characteristics determined by Mayo Clinic in a manner consistent with CLIA requirements. It has not been cleared or approved by the US Food and Drug Administration.

CPT Code Information

82542

LOINC Code Information

Test ID Test Order Name Order LOINC Value
HYOX Hyperoxaluria Panel, U 53710-0

 

Result ID Test Result Name Result LOINC Value
50592 Glycolate 13751-3
50593 Glycerate 13749-7
50594 Oxalate 13483-3
38049 4-hydroxy-2-oxoglutarate 13678-8
29982 Interpretation 59462-2
29984 Reviewed By 18771-6

Testing Algorithm

For more information see Hyperoxaluria Diagnostic Algorithm.

Interpretation

Increased concentrations of oxalate and glycolate indicate type 1 primary hyperoxaluria.

 

Increased concentrations of oxalate and glycerate indicate type 2 primary hyperoxaluria.

 

Increased concentrations of oxalate and 4-hydroxy-2-oxoglutarate indicate type 3 primary hyperoxaluria.

 

Increased concentrations of oxalate with normal concentrations of glycolate, glycerate, and 4-hydroxy-2-oxoglutarate indicate secondary hyperoxaluria.

Clinical Reference

1. Bhasin B, Urekli HM, Atta MG. Primary and secondary hyperoxaluria: Understanding the enigma. World J Nephrol. 2015;4(2):235-244. doi:10.5527/wjn.v4.i2.235

2. Michael M, Harvey E, Milliner DS, et al. Diagnosis and management of primary hyperoxalurias: best practices. Pediatr Nephrol. 2024;39(11):3143-3155. doi:10.1007/s00467-024-06328-2

3. Milliner DS, Harris PC, Cogal AG, et al. Primary hyperoxaluria type 1. In: Adam MP, Mirzaa GM, Pagon RA, et al, eds. GeneReviews [Internet]. University of Washington, Seattle; 2002. Updated August 15, 2024. Accessed September 23, 2025. Available at: www.ncbi.nlm.nih.gov/books/NBK1283/

4. Rumsby G, Hulton SA. Primary hyperoxaluria type 2. In: Adam MP, Mirzaa GM, Pagon RA, et al, eds. GeneReviews [Internet]. University of Washington, Seattle; 2008. Updated December 21, 2017. Accessed September 23, 2025. Available at: www.ncbi.nlm.nih.gov/books/NBK2692/

5. Milliner DS, Harris PC, Sas DJ, Lieske JC. Primary hyperoxaluria type 3. In: Adam MP, Mirzaa GM, Pagon RA, et al, eds. GeneReviews [Internet]. University of Washington, Seattle; 2015. Updated February 9, 2023. Accessed September 23, 2025. Available at: www.ncbi.nlm.nih.gov/books/NBK316514/

6. Fraser AD: Importance of glycolic acid analysis in ethylene glycol poisoning. Clin Chem. 1998;44(8):1769

Report Available

3 to 9 days

Method Name

Gas Chromatography Mass Spectrometry (GC-MS)

Forms

1. Biochemical Genetics Patient Information (T602)

2. If not ordering electronically, complete, print, and send 1 of the following forms with the specimen:

-Biochemical Genetics Test Request (T798)

-Renal Diagnostics Test Request (T830)