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Test Code HRSPF Horse Dander, IgE with Reflex to Horse Dander Component, IgE, Serum


Ordering Guidance


For a listing of allergens available for testing, see Allergens - Immunoglobulin E (IgE) Antibodies



Specimen Required


Collection Container/Tube:

Preferred: Serum gel

Acceptable: Red top

Submission Container/Tube: Plastic vial

Specimen Volume: 0.6 mL

Collection Instructions: Centrifuge and aliquot serum into a plastic vial.


Useful For

Evaluating patients with suspected horse dander allergy

Reflex Tests

Test ID Reporting Name Available Separately Always Performed
HRSPR Horse Dander Component, IgE, S No No

Testing Algorithm

Testing begins with analysis of total horse dander IgE. If horse dander total IgE is negative (<0.10 kU/L), testing is complete.

 

If horse dander total IgE is 0.10 kU/L or more, then horse dander component (Equ c 1) testing is performed at an additional charge.

Method Name

Fluorescent Enzyme Immunoassay (FEIA)

Reporting Name

Horse Dander Component Reflex, S

Specimen Type

Serum

Specimen Minimum Volume

0.4 mL

Specimen Stability Information

Specimen Type Temperature Time Special Container
Serum Refrigerated (preferred) 14 days
  Frozen  90 days

Reference Values

Class

IgE kU/L

Interpretation

0

<0.10

Negative

0/1

0.10-0.34

Borderline/equivocal

1

0.35-0.69

Equivocal

2

0.70-3.49

Positive

3

3.50-17.4

Positive

4

17.5-49.9

Strongly positive

5

50.0-99.9

Strongly positive

6

≥100

Strongly positive

Concentrations of 0.70 kU/L or more (class 2 and above) will flag as abnormally high.

Reference values apply to all ages.

Interpretation

When detectable total horse dander IgE antibody is present (≥0.10 IgE kUa/L), additional specific component IgE antibody testing will be performed. If the specific allergenic horse dander component IgE is detectable (≥0.10 IgE kUa/L), an interpretative report will be provided.

 

When the sample is negative for total horse dander IgE antibody (<0.10 IgE kUa/L), additional testing for specific horse dander component IgE antibodies will not be performed. Negative IgE results for total horse dander antibody may indicate a lack of sensitization to potential horse dander allergenic components.

Clinical Reference

1. Arseneau AM, Hrabak TM, Waibel KH. Inhalant horse allergens and allergies: a review of the literature. Mil Med. 2012;177(7):877-882

2.Salo PM, Arbes SJ Jr, Jaramillo R, et al: Prevalence of allergic sensitization in the United States: results from the National Health and Nutrition Examination Survey (NHANES) 2005-2006. J Allergy Clin Immunol. 2014;134(2):350-359. doi:10.1016/j.jaci.2013.12.1071

3.Guida G, Nebiolo F, Heffler E, Bergia R, Rolla G: Anaphylaxis after a horse bite. Allergy. 2005;60(8):1088-1089

4.Saarelainen S, Rytkonen-Nissinen M, Rouvinen J, et al: Animal-derived lipocalin allergens exhibit immunoglobulin E cross-reactivity. Clin Exp Allergy. 2008 Feb;38(2):374-381

5.Chan SK, Leung DYM: Dog and cat allergies: Current state of diagnostic approaches and challenges. Allergy Asthma Immunol Res. 2018 Mar;10(2):97-105. doi: 10.4168/aair.2018.10.2.97

6.Chruszcz M, Mikolajczak K, Mank N, Majorek KA, Porebski PJ, Minor W: Serum albumins-unusual allergens. Biochim Biophys Acta. 2013;1830(12):5375-81

7.Nwaru BI, Suzuki S, Ekerljung L, et al: Furry animal allergen component sensitization and clinical outcomes in adult asthma and rhinitis. J Allergy Clin Immunol Pract..2019 Apr;7(4):1230-1238.e4

8.Hilger C, van Hage M, Kuehn A: Diagnosis of allergy to mammals and fish: Cross-reactive vs. specific markers. Curr Allergy Asthma Rep. 2017 Aug 22;17(9):64

Day(s) Performed

Monday through Friday

Report Available

Same day/1 to 3 days

Performing Laboratory

Mayo Clinic Laboratories in Rochester

Test Classification

This test has been cleared, approved, or is exempt by the US Food and Drug Administration and is used per manufacturer's instructions. Performance characteristics were verified by Mayo Clinic in a manner consistent with CLIA requirements.

CPT Code Information

86003

LOINC Code Information

Test ID Test Order Name Order LOINC Value
HRSPF Horse Dander Component Reflex, S 6143-2

 

Result ID Test Result Name Result LOINC Value
HORS1 Horse Dander, IgE, S 6143-2

Forms

If not ordering electronically, complete, print, and send an Allergen Test Request (T236) with the specimen.