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Test Code HIBC Histoplasma/Blastomyces Panel, Spinal Fluid


Specimen Required


Container/Tube: Sterile vial

Specimen Volume: 1.5 mL

Collection Instructions: Submit specimen from collection vial number 1.


Useful For

Aiding in the diagnosis of histoplasmosis or blastomycosis meningitis

Profile Information

Test ID Reporting Name Available Separately Always Performed
HICSF Histoplasma Ab CompFix/ImmDiff, CSF Yes Yes
CBL Blastomyces Ab Immunodiffusion, CSF Yes Yes

Testing Algorithm

For information see Meningitis/Encephalitis Panel Algorithm

Method Name

HICSF: Complement Fixation (CF)/Immunodiffusion (ID)

CBL: Immunodiffusion (ID)

Reporting Name

Histoplasma/Blastomyces Panel,CSF

Specimen Type

CSF

Specimen Minimum Volume

1 mL

Specimen Stability Information

Specimen Type Temperature Time
CSF Refrigerated (preferred) 14 days
  Frozen  14 days

Reference Values

HISTOPLASMA ANTIBODY

Anti-Yeast antibody by Complement Fixation: Negative

Antibody by Immunodiffusion: Negative

 

BLASTOMYCES ANTIBODY IMMUNODIFFUSION

Negative

Interpretation

Histoplasma:

Any positive serologic result in spinal fluid is significant.

 

Blastomyces:

Any positive result in spinal fluid is significant.

Clinical Reference

1. Kaufman L, Kovacs JA, Reiss E: Clinical immunomycology. In: Rose NL, Conway-de Macario E, Folds JD, Lane HC, Nakamura RM, eds. Manual of Clinical Laboratory Immunology. ASM Press; 1997:588-589

2. Gauthier GM, Klein BS: Blastomycosis. In: Bennett JE, Dolin R, Blaser MJ, eds. Mandell, Douglas, and Bennett's Principles and Practice of Infectious Diseases. 9th ed. Elsevier; 2020:3177-3189

3. Deepe GS: Histoplasma capsulatum Histoplasmosis. In: Bennett JE, Dolin R, Blaser MJ, eds. Mandell, Douglas, and Bennett's Principles and Practice of Infectious Diseases. 9th ed. Elsevier; 2020:3162-3176

4. Theel ES, Kus JV, Grys TE, Ampel NM, Schwartz IS, Zhang SX. Practical Guidance for Clinical Microbiology Laboratories: Antibody and antigen detection methods for dimorphic fungal infections. Clin Microbiol Rev. 2025;38(2):e0000520. doi:10.1128/cmr.00005-20

Day(s) Performed

Monday through Friday

Report Available

3 to 7 days

Performing Laboratory

Mayo Clinic Laboratories in Rochester

Test Classification

This test has been cleared, approved, or is exempt by the US Food and Drug Administration and is used per manufacturer's instructions. Performance characteristics were verified by Mayo Clinic in a manner consistent with CLIA requirements.

CPT Code Information

86698 x2

86612

LOINC Code Information

Test ID Test Order Name Order LOINC Value
HIBC Histoplasma/Blastomyces Panel,CSF 91683-3

 

Result ID Test Result Name Result LOINC Value
15134 Blastomyces Immunodiffusion (CSF) 51741-7
621217 Histoplasma Yeast CompFix, CSF 27209-6
621218 Histoplasma Immunodiffusion, CSF 91682-5