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Test Code HEXP Iohexol, Plasma

Reporting Name

Iohexol, P

Useful For

Determining glomerular filtration rate in plasma specimens

Performing Laboratory

Mayo Clinic Laboratories in Rochester

Specimen Type

Plasma Heparin


Specimen Required


Supplies: Sarstedt Aliquot Tube, 5 mL (T914)

Collection Container/Tube: Green top (heparin)

Submission Container/Tube: Plastic vial

Specimen Volume: 1 mL

Collection Instructions: Centrifuge and aliquot plasma into a plastic vial.


Specimen Minimum Volume

0.5 mL

Specimen Stability Information

Specimen Type Temperature Time Special Container
Plasma Heparin Refrigerated (preferred) 7 days
  Frozen  35 days
  Ambient  7 days

Reference Values

Not applicable

Day(s) Performed

Monday through Friday

Test Classification

This test was developed and its performance characteristics determined by Mayo Clinic in a manner consistent with CLIA requirements. It has not been cleared or approved by the US Food and Drug Administration.

CPT Code Information

82542

LOINC Code Information

Test ID Test Order Name Order LOINC Value
HEXP Iohexol, P 93974-4

 

Result ID Test Result Name Result LOINC Value
61713 Iohexol, P 93974-4

Interpretation

Low glomerular filtration rate (GFR) values indicate abnormal kidney function, which may be either reversible/transient or irreversible/permanent. GFR tends to decline with age.

Clinical Reference

1. Brown SC, O'Reilly PH. Iohexol clearance for the determination of glomerular filtration rate in clinical practice: evidence for a new gold standard. J Urol. 1991;146:675-679

2. Gaspari F, Perico N, Ruggenenti P, et al. Plasma clearance of nonradioactive iohexol as a measure of glomerular filtration rate. J Am Soc Nephrol. 1995;6:257-263

3. Schwartz GJ, Abraham AG, Furth SL, et al. Optimizing iohexol plasma disappearance curves to measure the glomerular filtration rate in children with chronic kidney disease. Kidney Int. 2010;77:65-71

4. Schmit DJ, Carroll LJ, Eckfeldt JH, Seegmiller JC. Verification of separate measurement procedures where analytical determinations influence the clinical interpretation of GFR: Iohexol quantitation by HPLC and LC-MS/MS. Clin Biochem. 2019;67:16-23

5. Seegmiller JC, Burns BE, Schinstock CA, Lieske JC, Larson TS. Discordance between iothalamate and iohexol urinary clearances. Am J Kid Dis. 2016;67(1):49-55

Report Available

3 to 4 days

Method Name

Liquid Chromatography Tandem Mass Spectrometry (LC-MS/MS)

Forms

If not ordering electronically, complete, print, and send a Renal Diagnostics Test Request (T830) with the specimen.