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Test Code HEVG Hepatitis E Virus IgG Antibody, Serum

Reporting Name

HEV IgG Ab, S

Useful For

Diagnosis of past exposure to hepatitis E virus

Performing Laboratory

Mayo Clinic Laboratories in Rochester

Specimen Type

Serum SST


Necessary Information


Date of collection is required.



Specimen Required


Supplies: Sarstedt Aliquot Tube, 5 mL (T914)

Collection Container/Tube: Serum gel

Submission Container/Tube: Plastic vial

Specimen Volume: 0.5 mL

Collection Instructions:

1. Centrifuge blood collection tube per collection tube manufacturer's instructions (eg, centrifuge within 2 hours of collection for BD Vacutainer tubes).

2. Aliquot serum into a plastic vial.


Specimen Minimum Volume

See Specimen Required

Specimen Stability Information

Specimen Type Temperature Time
Serum SST Frozen (preferred)
  Refrigerated  24 hours

Reference Values

Negative

Day(s) Performed

Wednesday, Friday

Test Classification

This test was developed and its performance characteristics determined by Mayo Clinic in a manner consistent with CLIA requirements. It has not been cleared or approved by the US Food and Drug Administration.

CPT Code Information

86790

LOINC Code Information

Test ID Test Order Name Order LOINC Value
HEVG HEV IgG Ab, S 49693-5

 

Result ID Test Result Name Result LOINC Value
86211 HEV IgG Ab, S 49693-5

Interpretation

Positive results indicate past or resolved hepatitis E infection.

 

Negative results indicate absence of previous exposure to hepatitis E virus (HEV).

 

Borderline results may be seen in acute or recent hepatitis E infection with rising level of anti-HEV IgG or cross-reactivity with nonspecific antibodies (ie, false-positive results). Repeat testing of serum for anti-HEV IgG in 4 to 6 weeks is recommended to determine the definitive HEV infection status.

Clinical Reference

1. Aggarwal R: Diagnosis of hepatitis E. Nat Rev Gastroenterol Hepatol. 2013;10(1):24-33

2. Schemmerer M, Rauh C, Jilg W, Wenzel JJ. Time course of hepatitis E-specific antibodies in adults. J Viral Hepat. 2017;24(1):75-79. doi:10.1111/jvh.12621

3. European Association for the Study of the Liver. EASL Clinical Practice Guidelines on hepatitis E virus infection. J Hepatol. 2018;68(6):1256-1271. doi:10.1016/j.jhep.2018.03.005

4. Kar P, Karna R. A Review of the Diagnosis and Management of Hepatitis E. Curr Treat Options Infect Dis. 2020;12(3):310-320. doi:10.1007/s40506-020-00235-4

Report Available

1 to 7 days

Method Name

Enzyme Immunoassay (EIA)

Testing Algorithm

For information see Hepatitis E: Testing Algorithm for Diagnosis and Management.

Forms

If not ordering electronically, complete, print, and send 1 of the following:

-Gastroenterology and Hepatology Test Request (T728)

-Infectious Disease Serology Test Request (T916)

-Microbiology Test Request (T244)