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HelpTest Code HAPT Haptoglobin, Serum
Reporting Name
Haptoglobin, SUseful For
Confirmation of intravascular hemolysis
Performing Laboratory
Mayo Clinic Laboratories in Rochester
Specimen Type
SerumSpecimen Required
Supplies: Sarstedt Aliquot Tube, 5 mL (T914)
Collection Container/Tube:
Preferred: Serum gel
Acceptable: Red top
Submission Container/Tube: Plastic vial
Specimen Volume:1 mL
Collection Instructions: Centrifuge and aliquot serum into a plastic vial.
Specimen Minimum Volume
0.5 mL
Specimen Stability Information
| Specimen Type | Temperature | Time | Special Container |
|---|---|---|---|
| Serum | Refrigerated (preferred) | 28 days | |
| Frozen | 28 days | ||
| Ambient | 14 days |
Reference Values
30-200 mg/dL
Day(s) Performed
Monday through Friday
Test Classification
This test has been cleared, approved, or is exempt by the US Food and Drug Administration and is used per manufacturer's instructions. Performance characteristics were verified by Mayo Clinic in a manner consistent with CLIA requirements.CPT Code Information
83010
LOINC Code Information
| Test ID | Test Order Name | Order LOINC Value |
|---|---|---|
| HAPT | Haptoglobin, S | 46127-7 |
| Result ID | Test Result Name | Result LOINC Value |
|---|---|---|
| HAPT | Haptoglobin, S | 46127-7 |
Interpretation
Absence of plasma haptoglobin may indicate intravascular hemolysis. However, congenital anhaptoglobinemia is common, particularly in African Americans. For this reason, it may be difficult or impossible to interpret a single measurement of plasma haptoglobin. If the assay value is low, the test should be repeated after 1 to 2 weeks following an acute episode of hemolysis. If all the plasma haptoglobin is removed following an episode of intravascular hemolysis and if hemolysis ceases, the haptoglobin concentration should return to normal in a week.
Low levels of plasma haptoglobin may indicate intravascular hemolysis.
Clinical Reference
1. Shih AW, McFarlane A, Verhovsek M. Haptoglobin testing in hemolysis: measurement and interpretation. Am J Hematol. 2014;89(4):443-447. doi:10.1002/ajh.23623
2. di Masi A, De Simone G, Ciaccio C, D'Orso S, Coletta M, Ascenzi P. Haptoglobin: From hemoglobin scavenging to human health. Mol Aspects Med. 2020;73:100851. doi:10.1016/j.mam.2020.100851
3. Rifai N. Tietz Textbook of Laboratory Medicine. 7th ed. Elsevier; 2022:1584
Report Available
1 to 3 daysMethod Name
Nephelometry