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Test Code FL Fluoride, Plasma

Reporting Name

Fluoride, P

Useful For

Assessing accidental fluoride ingestion

 

Monitoring patients receiving sodium fluoride for bone disease or patients receiving voriconazole therapy

Performing Laboratory

Mayo Clinic Laboratories in Rochester

Specimen Type

Plasma Heparin


Specimen Required


Supplies: Sarstedt Aliquot Tube, 5 mL (T914)

Collection Container/Tube: Green top (sodium heparin)

Submission Container/Tube: Plastic vial

Specimen Volume: 3 mL

Collection Instructions: Centrifuge and aliquot plasma into a plastic vial. Glass tubes are not acceptable.


Specimen Minimum Volume

1.2 mL

Specimen Stability Information

Specimen Type Temperature Time Special Container
Plasma Heparin Refrigerated (preferred) 14 days
  Ambient  14 days
  Frozen  14 days

Reference Values

<4.1 mcmol/L

Day(s) Performed

Tuesday

Test Classification

This test was developed and its performance characteristics determined by Mayo Clinic in a manner consistent with CLIA requirements. It has not been cleared or approved by the US Food and Drug Administration.

CPT Code Information

82735

LOINC Code Information

Test ID Test Order Name Order LOINC Value
FL Fluoride, P 14726-4

 

Result ID Test Result Name Result LOINC Value
8641 Fluoride, P 14726-4

Interpretation

Humans exposed to fluoride-treated water typically have plasma fluoride in the range of 1 to 4 mcmol/L. Those who are not drinking fluoride-treated water have plasma fluoride less than 1 mcmol/L. Plasma fluoride values greater than 4 mcmol/L indicate excessive exposure and are associated with periostitis.

Clinical Reference

1. Cardos VES, Whitford GH, Aoyama H, et al. Daily variations in human plasma fluoride concentrations. J Fluorine Chem. 2008:129;1193-1198

2. Wermers RA, Cooper K, Razonable RR, et al. Fluoride excess and periostitis in transplant patients receiving long-term voriconazole therapy. Clin Infect Dis. 2011 1;52(5):604-611

3. Agency for Toxic Substances and Disease Registry: Toxicological profile for fluorides, hydrogen fluoride, and fluorine. US Department of Health and Human Services 2003. Accessed February 09, 2024. Available at www.atsdr.cdc.gov/ToxProfiles/tp11.pdf

4. Sodi R: Vitamins and trace elements. In: Rifai N, Chiu RWK, Young I, Burnham CD, Wittwer CT, eds. Tietz Textbook of Laboratory Medicine. 7th ed. Elsevier; 2023:chap 39

Report Available

2 to 8 days

Method Name

Ion-Selective Electrode (ISE)